Celiac DiseaseSymptoms, Doctors, Treatments, Advances & More
Learn About Celiac Disease
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.
The risk of developing celiac disease is increased by certain variants of the HLA-DQA1 and HLA-DQB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system. The HLA-DQA1 and HLA-DQB1 genes belong to a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Celiac disease is a common disorder. Its prevalence has been estimated at about 1 in 100 people worldwide.
Celiac disease tends to cluster in families. Parents, siblings, or children (first-degree relatives) of people with celiac disease have between a 4 and 15 percent chance of developing the disorder. However, the inheritance pattern is unknown.
Cleveland Clinic Main Campus
Alberto Tapia is a Gastroenterologist practicing medicine in Cleveland, Ohio. Dr. Tapia is rated as an Elite provider by MediFind in the treatment of Celiac Disease. He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Celiac Disease, Malabsorption, Diarrhea, Tropical Sprue, and Endoscopy. Dr. Tapia is board certified in American Board Of Internal Medicine, 2019.
BIDMC - Division Of Gastroenterology/GI East
Daniel Leffler is an Internal Medicine provider practicing medicine in Boston, Massachusetts. Dr. Leffler is rated as an Elite provider by MediFind in the treatment of Celiac Disease. He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Celiac Disease, Malabsorption, Diarrhea, Colonoscopy, and Endoscopy. Dr. Leffler is board certified in American Board Of Internal Medicine.
Cleveland Clinic Main Campus
Claire Jansson is a Gastroenterologist practicing medicine in Cleveland, Ohio. She has been practicing medicine for over 17 years. Dr. Jansson is rated as an Elite provider by MediFind in the treatment of Celiac Disease. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Celiac Disease, Malabsorption, Lactose Intolerance, Colonoscopy, and Endoscopy. Dr. Jansson is board certified in American Board Of Internal Medicine, 2021.
Summary: GLU001 is a first-in-human clinical trial to assess the safety and tolerability of VTP-1000 for adults with celiac disease. This trial will assess VTP-1000 at various dose levels compared to placebo in a single ascending dose (SAD) and multiple ascending dose (MAD) format. Participants will be followed for a short period of time to assess the impact of VTP-1000 on their immune system (Adverse even...
Summary: The aim of this observational study is to evaluate the impact of raw cornstarch supplementation on postprandial glycemic response in adult patients with Glycogen Storage Disease type I (GSD I), using continuous glucose monitoring (CGM) systems.GSD I is a rare inherited metabolic disorder characterized by impaired glucose homeostasis during fasting, leading to recurrent hypoglycemia and metabolic a...
Published Date: April 01, 2019
Published By: National Institutes of Health