Celiac Disease Overview
Learn About Celiac Disease
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.
The risk of developing celiac disease is increased by certain variants of the HLA-DQA1 and HLA-DQB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system. The HLA-DQA1 and HLA-DQB1 genes belong to a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Celiac disease is a common disorder. Its prevalence has been estimated at about 1 in 100 people worldwide.
Celiac disease tends to cluster in families. Parents, siblings, or children (first-degree relatives) of people with celiac disease have between a 4 and 15 percent chance of developing the disorder. However, the inheritance pattern is unknown.
Ira Merkel is a Gastroenterologist in Somerset, New Jersey. Dr. Merkel and is rated as an Advanced provider by MediFind in the treatment of Celiac Disease. His top areas of expertise are Irritable Bowel Syndrome (IBS), Celiac Disease, Diverticular Disease, Gastrectomy, and Endoscopy.
Rutgers Health-Rwj Scleroderma Program
Ellen Stein is a Gastroenterologist in New Brunswick, New Jersey. Dr. Stein has been practicing medicine for over 21 years and is rated as an Experienced provider by MediFind in the treatment of Celiac Disease. Her top areas of expertise are Gastroparesis, Encopresis, Gastric Dysmotility, Endoscopy, and Gastrectomy.
Allied Digestive Health LLC
Mauricio Zapiach is a Gastroenterologist in Somerset, New Jersey. Dr. Zapiach and is rated as an Experienced provider by MediFind in the treatment of Celiac Disease. His top areas of expertise are Attenuated Familial Adenomatous Polyposis, Cronkhite-Canada Disease, Juvenile Polyposis Syndrome, Gastrectomy, and Gastrostomy.
Summary: The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in indivi...
Summary: This is a prospective, randomized, double-blind, placebo-controlled exploratory trial to evaluate the effect of L-tryptophan supplementation on celiac-related symptoms in individuals who have biopsy-confirmed celiac disease (CeD) and symptoms non-responsive to a gluten-free diet (GFD). Fifty participants, aged 18 to 75 years, who self-report persistent CeD-related symptoms despite taking a GFD for...
Published Date: April 01, 2019
Published By: National Institutes of Health