Celiac DiseaseSymptoms, Doctors, Treatments, Advances & More
Learn About Celiac Disease
Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.
The risk of developing celiac disease is increased by certain variants of the HLA-DQA1 and HLA-DQB1 genes. These genes provide instructions for making proteins that play a critical role in the immune system. The HLA-DQA1 and HLA-DQB1 genes belong to a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.
Celiac disease is a common disorder. Its prevalence has been estimated at about 1 in 100 people worldwide.
Celiac disease tends to cluster in families. Parents, siblings, or children (first-degree relatives) of people with celiac disease have between a 4 and 15 percent chance of developing the disorder. However, the inheritance pattern is unknown.
BIDMC - Division Of Gastroenterology/GI East
Daniel Leffler is an Internal Medicine provider in Boston, Massachusetts. Dr. Leffler is rated as an Elite provider by MediFind in the treatment of Celiac Disease. His top areas of expertise are Celiac Disease, Malabsorption, Diarrhea, Colonoscopy, and Endoscopy.
Cleveland Clinic Main Campus
Alberto Tapia is a Gastroenterologist in Cleveland, Ohio. Dr. Tapia is rated as an Elite provider by MediFind in the treatment of Celiac Disease. His top areas of expertise are Celiac Disease, Malabsorption, Diarrhea, Tropical Sprue, and Endoscopy.
Cleveland Clinic Main Campus
Claire Jansson is a Gastroenterologist in Cleveland, Ohio. Dr. Jansson has been practicing medicine for over 17 years and is rated as an Elite provider by MediFind in the treatment of Celiac Disease. Her top areas of expertise are Celiac Disease, Malabsorption, Lactose Intolerance, Colonoscopy, and Endoscopy.
Summary: The primary efficacy objective of the trial is to assess the ability of TEV-53408 to attenuate gluten-induced enteropathy in adults with celiac disease. The primary safety objective of the trial is to assess the safety of TEV-53408 in adults with celiac disease. A secondary objective is to further assess the efficacy of TEV-53408 in adults with celiac disease. The expected trial duration per parti...
Summary: The investigators propose the Gluten Free Nutrition Optimization through Ultra-processed food Reduction and Improved Strategies for Health (GF-NOURISH) study to demonstrate the feasibility and success of a nutritional education program focused on naturally occurring gluten-free foods and minimizing ultra-processed gluten-free foods. The investigators hypothesize that nutritional educational (GF-NO...
Published Date: April 01, 2019
Published By: National Institutes of Health