Learn About Cerebellar Multiple System Atrophy

What is the definition of Cerebellar Multiple System Atrophy?

Multiple system atrophy - cerebellar subtype (MSA-C) is a rare disease that causes areas deep in the brain, just above the spinal cord, to shrink (atrophy). MSA-C used to be known as olivopontocerebellar atrophy (OPCA).

What are the alternative names for Cerebellar Multiple System Atrophy?

MSA-C; Cerebellar multiple system atrophy; Olivopontocerebellar atrophy; OPCA; Olivopontocerebellar degeneration

What are the causes of Cerebellar Multiple System Atrophy?

MSA-C can be passed down through families (inherited form). It can also affect people without a known family history (sporadic form).

Researchers have identified certain genes that are involved in the inherited form of this condition.

The cause of MSA-C in people with the sporadic form is not known. The disease slowly gets worse (is progressive).

MSA-C is slightly more common in men than in women. The average age of onset is 54 years.

What are the symptoms of Cerebellar Multiple System Atrophy?

Symptoms of MSA-C tend to start at a younger age in people with the inherited form. The main symptom is clumsiness (ataxia) that slowly gets worse. There may also be problems with balance, slurring of speech, and difficulty walking.

Other symptoms may include:

  • Abnormal eye movements
  • Abnormal movements
  • Abnormal sweating
  • Bowel or bladder problems
  • Difficulty swallowing
  • Cold hands and feet
  • Lightheadedness when standing
  • Headache while standing that is relieved by lying down
  • Muscle stiffness or rigidity, spasms, tremor
  • Nerve damage (neuropathy)
  • Problems in speaking and sleeping due to spasms of the vocal cords
  • Sexual function problems
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What are the current treatments for Cerebellar Multiple System Atrophy?

There is no specific treatment or cure for MSA-C. The aim is to treat the symptoms and prevent complications. This may include:

  • Tremor medicines, such as those for Parkinson disease
  • Speech, occupational and physical therapy
  • Ways to prevent choking
  • Walking aids to help with balance and prevent falls
  • Devices to treat sleep apnea (such as CPAP)
  • Treatment for low blood pressure
Who are the top Cerebellar Multiple System Atrophy Local Doctors?

Mgmc LLC

3800 Reservoir Rd Nw, 
Washington, DC 
 2.1 mi
Offers Telehealth

Fernando Pagan is a Neurologist in Washington, Washington, D.c.. Dr. Pagan and is rated as an Advanced provider by MediFind in the treatment of Cerebellar Multiple System Atrophy. His top areas of expertise are Parkinson's Disease, Benign Essential Blepharospasm, Lewy Body Dementia (LBD), Orthostatic Hypotension, and Deep Brain Stimulation.

1140 Varnum St Ne, Suite #101, 
Washington, DC 
 3.5 mi

William Peterson is a Neurologist in Washington, Washington, D.c.. Dr. Peterson and is rated as an Advanced provider by MediFind in the treatment of Cerebellar Multiple System Atrophy. His top areas of expertise are Vitamin B12 Deficiency, Subacute Combined Degeneration, Seizures, and Cerebellar Multiple System Atrophy.

 
 
 
 
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Medstar Medical Group Ii LLC

1145 19th St Nw, 311 Mmg At 19th Street Nw, 
Washington, DC 
 0.4 mi
Accepting New Patients

Peter Turkeltaub is a Neurologist in Washington, Washington, D.c.. Dr. Turkeltaub and is rated as an Experienced provider by MediFind in the treatment of Cerebellar Multiple System Atrophy. His top areas of expertise are Stroke, Apraxia, Primary Progressive Aphasia, and Frontotemporal Dementia. Dr. Turkeltaub is currently accepting new patients.

What are the support groups for Cerebellar Multiple System Atrophy?

More information and support for people with MSA-C and their families can be found at:

  • Defeat MSA Alliance -- defeatmsa.org/patient-programs/
  • Mission MSA -- missionmsa.org/resource-library/
What is the outlook (prognosis) for Cerebellar Multiple System Atrophy?

MSA-C slowly gets worse, and there is no cure. The outlook is generally poor. But, it may be years before someone is very disabled.

What are the possible complications of Cerebellar Multiple System Atrophy?

Complications of MSA-C include:

  • Choking
  • Infection from inhaling food into the lungs (aspiration pneumonia)
  • Injury from falls
  • Nutrition problems due to difficulty swallowing
When should I contact a medical professional for Cerebellar Multiple System Atrophy?

Contact your health care provider if you have any symptoms of MSA-C. You will need to be seen by a neurologist. This is a specialist who treats nervous system problems.

What are the latest Cerebellar Multiple System Atrophy Clinical Trials?
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Who are the sources who wrote this article ?

Published Date: June 13, 2024
Published By: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Jancovic J. Parkinson disease and other movement disorders. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 96.

Jellinger KA. Neuropathology of movement disorders. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 104.

Ma MJ. Biopsy pathology of neurodegenerative disorders in adults. In: Perry A, Brat DJ, eds. Practical Surgical Neuropathology: A Diagnostic Approach. 2nd ed. Philadelphia, PA: Elsevier, 2018:chap 27.

Walsh RR, Krismer F, Galpern WR, et al. Recommendations of the global multiple system atrophy research roadmap meeting. Neurology. 2018;90(2):74-82. PMID: 29237794 pubmed.ncbi.nlm.nih.gov/29237794/.