Cerebral Cavernous MalformationSymptoms, Doctors, Treatments, Advances & More
Learn About Cerebral Cavernous Malformation
Cerebral cavernous malformations are collections of small blood vessels (capillaries) in the brain that are enlarged and irregular in structure. These capillaries have abnormally thin walls, and they lack other support tissues, such as elastic fibers, which normally make them stretchy. As a result, the blood vessels are prone to leakage, which can cause the health problems related to this condition. Cavernous malformations can occur anywhere in the body, but usually produce serious signs and symptoms only when they occur in the brain and spinal cord (which are described as cerebral).
Mutations in at least three genes, KRIT1 (also known as CCM1), CCM2, and PDCD10 (also known as CCM3), cause familial cerebral cavernous malformations.
Cerebral cavernous malformations affect about 16 to 50 per 10,000 people worldwide.
This condition has an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In the familial form, an affected person inherits the mutation from one affected parent.
UChicago Medicine Duchossois Center For Advanced Medicine - Hyde Park
Issam Awad is a Neurosurgery provider practicing medicine in Chicago, Illinois. Dr. Awad is rated as an Elite provider by MediFind in the treatment of Cerebral Cavernous Malformation. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Cerebral Cavernous Malformation, Hemangioma, Stroke, Thrombectomy, and Carotid Artery Surgery. Dr. Awad is board certified in Practicing Since1986 and Neurological Surgery. Dr. Awad is currently accepting new patients.
UChicago Medicine Duchossois Center For Advanced Medicine - Hyde Park
Sean Polster is a Neurosurgery provider practicing medicine in Chicago, Illinois. Dr. Polster is rated as an Elite provider by MediFind in the treatment of Cerebral Cavernous Malformation. He is also highly rated in 4 other conditions, according to our data. His clinical expertise encompasses Cerebral Cavernous Malformation, Hemangioma, Chordoma, Craniectomy, and Thrombectomy. Dr. Polster is board certified in Practicing Since2013 and Neurological Surgery. Dr. Polster is currently accepting new patients.
Hussein Zeineddine is a Neurosurgery provider practicing medicine in Houston, Texas. Dr. Zeineddine is rated as an Elite provider by MediFind in the treatment of Cerebral Cavernous Malformation. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Cerebral Cavernous Malformation, Hemangioma, Subarachnoid Hemorrhage, Craniectomy, and Endovascular Embolization. Dr. Zeineddine is currently accepting new patients.
Summary: The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technology. The study focuses on individuals who have been diagnosed with cerebral cavernous malformations (CCMs). Main Questions to Answer: How can AI-based radiomics features predict the risk of complication...
Summary: Patients with symptomatic and asymptomatic familial cerebral cavernous malformation (fCCM) will be included. The goal of this observational study is to learn about the long-term evolution of this condition. The subjects enrolled will be followed for two years and will undergo an annual neurological examination with the recording of clinical events, a brain MRI according to a dedicated protocol, an...
Published Date: April 01, 2020
Published By: National Institutes of Health