Cerebral Cavernous MalformationSymptoms, Doctors, Treatments, Advances & More
Learn About Cerebral Cavernous Malformation
Cerebral cavernous malformations are collections of small blood vessels (capillaries) in the brain that are enlarged and irregular in structure. These capillaries have abnormally thin walls, and they lack other support tissues, such as elastic fibers, which normally make them stretchy. As a result, the blood vessels are prone to leakage, which can cause the health problems related to this condition. Cavernous malformations can occur anywhere in the body, but usually produce serious signs and symptoms only when they occur in the brain and spinal cord (which are described as cerebral).
Mutations in at least three genes, KRIT1 (also known as CCM1), CCM2, and PDCD10 (also known as CCM3), cause familial cerebral cavernous malformations.
Cerebral cavernous malformations affect about 16 to 50 per 10,000 people worldwide.
This condition has an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In the familial form, an affected person inherits the mutation from one affected parent.
Avera Medical Group Dermatology — Mitchell
Mandi Greenway, MD, a dermatologist, provides expert skin care for people of all ages at Avera Medical Group Dermatology in Mitchell, SD. Dr. Greenway is rated as an Advanced provider by MediFind in the treatment of Cerebral Cavernous Malformation. She is also highly rated in 34 other conditions, according to our data. Her clinical expertise encompasses Actinic Keratosis, Warts, Seborrheic Keratosis, and Melanoma. Dr. Greenway is board certified in American Board Of Dermatology.
Avera Dermatology — Pierre
Dr. Katie Bonnichsen, a dermatologist, provides expert skin care at Avera Medical Group located in the Helmsley Center at Avera St. Mary's Hospital in Pierre, SD. Dr. Bonnichsen is rated as an Advanced provider by MediFind in the treatment of Cerebral Cavernous Malformation. She is also highly rated in 16 other conditions, according to our data. Her clinical expertise encompasses Actinic Keratosis, Seborrheic Keratosis, Warts, and Kaposiform Hemangioendothelioma. Dr. Bonnichsen is board certified in Eligible - American Board Of Dermatology.
Avera Dermatology — Pierre
Dr. (Joyce) Wesley Fletcher is a dermatologist at Avera Medical Group in Pierre, located in the Helmsley Center at Avera St. Mary's Hospital. Dr. Fletcher is rated as an Advanced provider by MediFind in the treatment of Cerebral Cavernous Malformation. She is also highly rated in 35 other conditions, according to our data. Her clinical expertise encompasses Familial Atypical Multiple Mole Melanoma Syndrome, Giant Congenital Melanocytic Nevus, Giant Congenital Nevus, and Neurocutaneous Melanosis.
Summary: The goal of this observational study is to evaluate and predict the risk associated with cerebral cavernous malformations (CCMs) using advanced artificial intelligence and radiomics analysis technology. The study focuses on individuals who have been diagnosed with cerebral cavernous malformations (CCMs). Main Questions to Answer: How can AI-based radiomics features predict the risk of complication...
Summary: Patients with symptomatic and asymptomatic familial cerebral cavernous malformation (fCCM) will be included. The goal of this observational study is to learn about the long-term evolution of this condition. The subjects enrolled will be followed for two years and will undergo an annual neurological examination with the recording of clinical events, a brain MRI according to a dedicated protocol, an...
Published Date: April 01, 2020
Published By: National Institutes of Health