Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Spasticity in Children With Hemiplegic Cerebral Palsy/ Hemiplegia Due to Acquired Brain Injury - a Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This RCT aims to investigate the effect of repetitive transcranial magnatic stimulation (rTMS) in treating children with hemiplegoc cerebral palsy. The study will measure any improvement in spasticity after using contra-lesional inhibitory rTMS follow by intensive limb training. Participants will attend a 10-day rTMS treatment sessions, follow by intensive training of the impaired limb. They will also undergo MRI scans before and after the treatment to investiagte the underlying neurophysiological mechanisms that lead to changes clinically by using TMS as well as MR-DKI. Researchers will compare the intervention group and the sham group to see if rTMS could result in improvement of participants' spasticity.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 7
Maximum Age: 18
Healthy Volunteers: f
View:

• Patients aged between 7 years and 18 years

• Diagnosis of cerebral palsy with hemiplegia

• Upper limb spasticity ≥ 1

• IQ ≥ 50

Locations
Other Locations
Hong Kong Special Administrative Region
Li Ka Shing Faculty of Medicine
RECRUITING
Hong Kong
Contact Information
Primary
Winnie Wan Yee Tso, MBBS
wytso@hku.hk
+85222554295
Backup
Oscar Lok Kan Leung, MSocSc
oscarlk@hku.hk
+85222554375
Time Frame
Start Date: 2024-01-13
Estimated Completion Date: 2025-07
Participants
Target number of participants: 20
Treatments
Experimental: Interventional rTMS group
The intervention group will receive 1 Hz active rTMS during treatment, lasting for 20 minutes, follow up by 30 minutes of intensive limb training.
Sham_comparator: Sham rTMS group
The sham group will not receive any Hz of rTMS during treatment, also lasting for 20 minutes with 30 minutes of intensive limb training afterwards.
Sponsors
Leads: The University of Hong Kong

This content was sourced from clinicaltrials.gov