Learn About Cheilitis Glandularis

What is the definition of Cheilitis Glandularis?
Cheilitis glandularis is a rare inflammatory disorder of the lip. It is mainly characterized by swelling of the lip with hyperplasia of the salivary glands; secretion of a clear, thick mucus; and variable inflammation. Enlargement and chronic exposure of the mucous membrane on the lower lip becomes affected by the environment, leading to erosion, ulceration, crusting, and, occasionally, infection. Cheilitis glandularis is more common in adult males, although cases have been described in women and children. In Caucasians, it is associated with a relatively high incidence of squamous cell carcinoma of the lip. Although there may be a genetic susceptibility, no definitive cause has been established. Treatment may include surgical excision by vermilionectomy (sometimes called a lip shave), but treatment varies for each individual.
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What are the current treatments for Cheilitis Glandularis?
The approach to treatment for cheilitis glandularis is typically based on information obtained from histopathologic analysis (microscopic examination of the tissue); the identification of the likely causes responsible for the condition; and attempts to alleviate or eradicate those causes. Given the relatively small number of reported cases of the condition, there is not sufficient or reliable data that exists with regard to medical approaches. Therefore, treatment generally varies accordingly for each individual.
  • For cases attributable to angioedema (swelling similar to hives beneath the skin), an antihistamine may help with temporary reduction of acute, nonpurulent (lacking pus) swelling.
  • Suppurative cases (those with pus present) typically require management with appropriate antimicrobial treatment as determined by culture and sensitivity testing. Concomitant corticosteroid treatment may increase the effectiveness of antimicrobial therapy in cases with nodularity; however, the potential adverse effects of long-term corticosteroid treatment, and because it can promote local fibrosis and scarring, limit its potential use either as an adjunct to antibiotic treatment or as a single therapeutic modality.
  • Topical 5-fluorouracil is useful for treatment of dysplastic actinic cheilitis and to curtail its progression. In conjunction with clinical supervision, it can be prescribed as an alternative to vermilionectomy (sometimes called a lip shave) or as a preventative measure following vermilionectomy.

In cheilitis glandularis cases in which a history of chronic sun exposure exists (especially if the individual is fair skinned or the everted lip surface is chronically eroded, ulcerated, or crusted), biopsy is strongly recommended to rule out actinic cheilitis or carcinoma.

  • Surgical excision is typically not necessary when the diagnosis is actinic cheilitis with atypia or only mild dysplasia; however, individuals require ongoing clinical vigilance at regular intervals and instruction in measures to protect the lips from further sun damage.
  • Treatment options for cases of actinic cheilitis with moderate-to-severe dysplasia include surgical stripping or vermilionectomy, cryosurgery or laser surgery, or topical chemotherapy with 5-fluorouracil. Given the potential for recurrence and the risk for development of carcinoma, sun protective measures and regular clinical monitoring should be instituted.
  • In cases in which eversion, extensive fibrosis, and induration have resulted in lip incompetence with functional and cosmetic compromise, chronic pain, and surface disruption, surgical cheiloplasty (lip reduction) may be indicated to restore normal lip architecture and function. Cheiloplasty is also a prophylactic measure for reducing the risk of actinic injury.
Who are the top Cheilitis Glandularis Local Doctors?
Highly rated in

Universidade De São Paulo

Sao Paulo, SP, BR 

Silvia Lourenco is in Sao Paulo, Brazil. Lourenco is rated as an Elite expert by MediFind in the treatment of Cheilitis Glandularis. She is also highly rated in 18 other conditions, according to our data. Her top areas of expertise are Cheilitis Glandularis, Melkersson-Rosenthal Syndrome, Sialadenitis, and Mouth Ulcers.

Highly rated in

Universidade De São Paulo

Sao Paulo, SP, BR 

Marcello Nico is in Sao Paulo, Brazil. Nico is rated as an Elite expert by MediFind in the treatment of Cheilitis Glandularis. They are also highly rated in 15 other conditions, according to our data. Their top areas of expertise are Cheilitis Glandularis, Melkersson-Rosenthal Syndrome, Cutaneous Lupus Erythematosus, and Anonychia Congenita.

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Highly rated in

Essentia Health Duluth Clinic

Duluth, MN 

Robert Stubenvoll is an Otolaryngologist in Duluth, Minnesota. Dr. Stubenvoll has been practicing medicine for over 41 years and is rated as a Distinguished doctor by MediFind in the treatment of Cheilitis Glandularis. He is also highly rated in 10 other conditions, according to our data. His top areas of expertise are Cheilitis Glandularis, Intertrigo, Otitis, and Nasal Polyps. He is licensed to treat patients in Minnesota.

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What are the Latest Advances for Cheilitis Glandularis?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.