Open Versus Laparoscopic Pancreaticoduodenectomy: A Randomized Controlled Trial
This is a monocentric, prospective, randomized controlled trial comparing the safety and efficacy of laparoscopic pancreaticoduodenectomy (LPD) versus open pancreaticoduodenectomy (OPD). The study aims to determine the morbimortality of the laparoscopic approach compared to the gold standard open approach in adult patients with pancreatic or periampullary lesions.
• Age ≥18 years.
• Histologically confirmed or clinically suspected lesions of: Pancreatic head adenocarcinoma, Ampullary carcinoma, Distal cholangiocarcinoma, Duodenal adenocarcinoma, Pancreatic neuroendocrine tumors, or Intraductal Papillary Mucinous Neoplasm(IPMN) .
• Resectable disease based on preoperative imaging.
• Eastern Cooperative Oncology Group(ECOG) performance status 0-2.
• American Society of Anesthesiologists(ASA )classification I-III.
• Patients able to provide informed consent.