Learn About Neuroendocrine Tumor

What is the definition of Neuroendocrine Tumor?
Neuroendocrine tumors are rare cancers that grow from neuroendocrine cells. Neuroendocrine cells receive signals from the nervous system to release hormones. There are several types of neuroendocrine tumors, although most occur in the lungs, pancreas, adrenal glands, small intestine, appendix, and rectum. Neuroendocrine tumors may also spread to the lymph nodes, liver, or bones.
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What are the symptoms of Neuroendocrine Tumor?
Symptoms of a neuroendocrine tumor depend on the tumor’s location and whether it is producing excess hormones. Symptoms of neuroendocrine tumors may include pain, a lump under the skin, fatigue, persistent cough or hoarseness, unexplained weight loss, confusion, anxiety, dizziness, shakiness, elevated blood glucose, low blood glucose, an ulcer, skin flushing, skin rash, increased thirst, nausea and vomiting, diarrhea, and carcinoid syndrome. Carcinoid syndrome is a condition that occurs when a neuroendocrine tumor produces excess hormones. Symptoms of carcinoid syndrome include skin flushing of the head and neck; sweating; shortness of breath; wheezing; rapid heartbeat; heart murmur; high blood pressure; yellowing of the skin and eyes; abdominal cramping; diarrhea; greasy, foul-smelling bowel movements; and swelling of the feet and legs.
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What are the current treatments for Neuroendocrine Tumor?
Treatment for neuroendocrine tumors depends on the type and location, as well as whether the tumor is producing excess hormones. Treatment for endocrine tumors may include surgery; chemotherapy; targeted drug therapy, such as everolimus and sunitinib; immunotherapy, such as interferon alfa-2b; peptide receptor radionuclide therapy; somatostatin analogs, such as octreotide and lanreotide; radiation therapy; radiofrequency ablation; and hepatic artery embolization.
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What are the latest Neuroendocrine Tumor Clinical Trials?
Nonfunctioning Small (≤2 cm) Neuroendocrine Pancreatic Incidentaloma: Clinical and Morphological Findings, and Therapeutic Options (IPANEMA)

Summary: Neuroendocrine tumors (NETs) and carcinomas account for 10-15 % of all pancreatic incidentalomas. The management of pancreatic NETs depends on tumor stage and on presence or not of hormonal syndrome. The therapeutic approach for hormonally functional tumor, or large tumor (> 2 cm) with local, vascular or lymph nodes invasion, highly suggestive of malignancy, or in presence of metastasis, is well a...

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Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma

Summary: This study will investigate how genetic and environmental factors contribute to the development of melanoma, a type of skin cancer, and related conditions. Individuals >= 2 years with a personal or family history of melanoma or atypical spitzoid/Spitz tumor may be eligible for this study. Participants will: Fill out one or two questionnaires about their personal and family medical history. Provide...

What are the Latest Advances for Neuroendocrine Tumor?
The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
Thymoquinone Plus Immunotherapy in Extra-Pulmonary Neuroendocrine Carcinoma: Case Series for a Novel Combination.
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Capecitabine and temozolomide for metastatic intermediate to high-grade pancreatic neuroendocrine neoplasm: a single center experience.