Cholestasis is any condition in which the flow of bile from the liver is slowed or blocked.
Intrahepatic cholestasis; Extrahepatic cholestasis
There are many causes of cholestasis.
Extrahepatic cholestasis occurs outside the liver. It can be caused by:
Intrahepatic cholestasis occurs inside the liver. It can be caused by:
Certain medicines can also cause cholestasis, including:
Symptoms may include:
The underlying cause of cholestasis must be treated.
Shyam Varadarajulu is a Gastroenterologist in Orlando, Florida. Varadarajulu has been practicing medicine for over 30 years and is rated as an Elite expert by MediFind in the treatment of Cholestasis. He is also highly rated in 28 other conditions, according to our data. His top areas of expertise are Hereditary Pancreatitis, Pancreatic Pseudocyst, Acute Pancreatitis, Endoscopy, and Stent Placement. Varadarajulu is currently accepting new patients.
Reem Sharaiha is a Gastroenterologist in New York, New York. Sharaiha has been practicing medicine for over 20 years and is rated as an Elite expert by MediFind in the treatment of Cholestasis. She is also highly rated in 33 other conditions, according to our data. Her top areas of expertise are Bile Duct Obstruction, Cholestasis, Bile Duct Stricture, Endoscopy, and Gastric Bypass.
Pietro Invernizzi practices in Monza (mb), Italy. Invernizzi is rated as an Elite expert by MediFind in the treatment of Cholestasis. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are Primary Biliary Cholangitis, Cholestasis, Cholangitis, Liver Transplant, and Pinealectomy.
How well a person does depends on the disease causing the condition. Stones in the common bile duct can often be removed. This can cure the cholestasis.
Stents can be placed to open areas of the common bile duct that are narrowed or blocked by cancers.
If the condition is caused by the use of a certain medicine, it will often go away when you stop taking that drug.
Complications may include:
Contact your health care provider if you have:
Get vaccinated for hepatitis A and B if you are at risk. Do not use intravenous drugs and share needles.
Summary: To evaluate the treatment effect of seladelpar on composite biochemical improvement in cholestasis markers based on ALP and total bilirubin and to evaluate the safety of seladelpar over 12 months of treatment compared to placebo
Summary: This is a multi-center prospective cross-sectional observational study that will assess the prevalence of liver disease in patients dependent on parenteral nutrition (PN) for 4 or more days per week. Liver disease will be determined by the presence of choline deficiency, cholestasis (confirmed by elevated serum alkaline phosphatase (ALP) liver isoenzyme level), and steatosis (confirmed by magnetic...
Published Date: May 04, 2022
Published By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Eaton JE, Lindor KD. Primary biliary cholangitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 91.
Fogel EL, Sherman S. Diseases of the gallbladder and bile ducts. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 146.
Lidofsky SD. Jaundice. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 21.