Learn About Cholestasis

What is the definition of Cholestasis?

Cholestasis is any condition in which the flow of bile from the liver is slowed or blocked.

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What are the alternative names for Cholestasis?

Intrahepatic cholestasis; Extrahepatic cholestasis

What are the causes of Cholestasis?

There are many causes of cholestasis.

Extrahepatic cholestasis occurs outside the liver. It can be caused by:

  • Bile duct tumors
  • Cysts
  • Narrowing of the bile duct (strictures)
  • Stones in the common bile duct
  • Pancreatitis
  • Pancreatic tumor or pseudocyst
  • Pressure on the bile ducts due to a nearby mass or tumor
  • Primary sclerosing cholangitis

Intrahepatic cholestasis occurs inside the liver. It can be caused by:

  • Alcoholic liver disease
  • Amyloidosis
  • Bacterial abscess in the liver
  • Being fed exclusively through a vein (IV)
  • Lymphoma
  • Pregnancy
  • Primary biliary cirrhosis
  • Primary or metastatic liver cancer
  • Primary sclerosing cholangitis
  • Sarcoidosis
  • Serious infections that have spread through the bloodstream (sepsis)
  • Tuberculosis
  • Viral hepatitis

Certain medicines can also cause cholestasis, including:

  • Antibiotics, such as ampicillin and other penicillins
  • Anabolic steroids
  • Birth control pills
  • Chlorpromazine
  • Cimetidine
  • Estradiol
  • Imipramine
  • Prochlorperazine
  • Terbinafine
  • Tolbutamide
What are the symptoms of Cholestasis?

Symptoms may include:

  • Clay-colored or white stools
  • Dark urine
  • Inability to digest certain foods
  • Itching
  • Nausea or vomiting
  • Pain in the right upper part of the abdomen
  • Yellow skin or eyes
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What are the current treatments for Cholestasis?

The underlying cause of cholestasis must be treated.

Who are the top Cholestasis Local Doctors?
Elite
Highly rated in
24
conditions
Gastroenterology

NewYork-Presbyterian Healthcare System

Weill Medical College Of Cornell

1283 York Ave 
New York, NY 10065

Reem Sharaiha is a Gastroenterologist in New York, New York. Dr. Sharaiha has been practicing medicine for over 19 years and is rated as an Elite doctor by MediFind in the treatment of Cholestasis. She is also highly rated in 24 other conditions, according to our data. Her top areas of expertise are Bile Duct Obstruction, Cholestasis, Bile Duct Stricture, and Hereditary Pancreatitis. She is licensed to treat patients in New York.

Elite
Highly rated in
27
conditions
Gastroenterology

Orlando Health Digestive Health Institute

52 W Underwood St 
Orlando, FL 32806

Shyam Varadarajulu is a Gastroenterologist in Orlando, Florida. Dr. Varadarajulu has been practicing medicine for over 29 years and is rated as an Elite doctor by MediFind in the treatment of Cholestasis. He is also highly rated in 27 other conditions, according to our data. His top areas of expertise are Pancreatic Pseudocyst, Hereditary Pancreatitis, Acute Pancreatitis, and Jaundice. He is licensed to treat patients in Florida. Dr. Varadarajulu is currently accepting new patients.

 
 
 
 
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Elite
Highly rated in
23
conditions

The Hospital For Sick Children

Toronto, ON, CA 

Binita Kamath is in Toronto, Canada. Kamath is rated as an Elite expert by MediFind in the treatment of Cholestasis. She is also highly rated in 23 other conditions, according to our data. Her top areas of expertise are Alagille Syndrome, Cholestasis, Biliary Hypoplasia, and Pulmonary Valve Stenosis.

What is the outlook (prognosis) for Cholestasis?

How well a person does depends on the disease causing the condition. Stones in the common bile duct can often be removed. This can cure the cholestasis.

Stents can be placed to open areas of the common bile duct that are narrowed or blocked by cancers.

If the condition is caused by the use of a certain medicine, it will often go away when you stop taking that drug.

What are the possible complications of Cholestasis?

Complications may include:

  • Diarrhea
  • Organ failure can occur if sepsis develops
  • Poor absorption of fat and fat-soluble vitamins
  • Severe itching
  • Weak bones (osteomalacia) due to having cholestasis for a very long time
When should I contact a medical professional for Cholestasis?

Call your health care provider if you have:

  • Itching that does not go away
  • Yellow skin or eyes
  • Other symptoms of cholestasis
How do I prevent Cholestasis?

Get vaccinated for hepatitis A and B if you are at risk. Do not use intravenous drugs and share needles.

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Gallbladder
Gallbladder
What are the latest Cholestasis Clinical Trials?
An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of A4250 in Children With Progressive Familial Intrahepatic Cholestasis Types 1 and 2 (PEDFIC 2)
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Evaluation Safety and Efficacy of Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation for Children Suffering From Liver Cirrhosis Due to Biliary Atresia: A Matched Control Prospective Study
What are the Latest Advances for Cholestasis?
Effect of Levothyroxine on Pregnancy Outcomes in Pregnant Women With Hypothyroxinemia: An Interventional Study.
Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial.
Tired of the same old research?
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Recurrent right hepatic artery pseudoaneurysm after robotic-assisted cholecystectomy in a patient with Mirizzi syndrome: a case report.
Who are the sources who wrote this article ?

Published Date : May 27, 2020
Published By : Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Eaton JE, Lindor KD. Primary biliary cholangitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 91.

Fogel EL, Sherman S. Diseases of the gallbladder and bile ducts. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 146.

Lidofsky SD. Jaundice. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 21.