Cholestasis Clinical Trials

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Preliminary Study: Effect of Nutrition Therapy on Prealbumin and IGF-1 Level in Severe Malnutrition Under Five Years Old With Chronic Cholestasis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if a high-energy liquid diet improves the nutritional status of children with chronic cholestasis (a liver condition that blocks bile flow). Researchers want to see if this diet helps children who are malnourished. The main questions the study aims to answer are: * Does the liquid diet raise the level of prealbumin (a marker of nutrition) in the blood? * Does the liquid diet raise the level of Insulin-like Growth Factor-1 (IGF-1) (a hormone that helps growth) in the blood? Participants will: * Consume a high-energy liquid diet for 14 days. * Give blood samples at the start and at the end of the 2-week study. * Keep a daily record of what they eat and drink in a food diary. Researchers will compare the blood test results from the start and the end of the study to see if the liquid diet works to improve the children's prealbumin and IGF-1 levels. This study is important to help children with liver problems grow better and stay healthy.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 5
Healthy Volunteers: f
View:

• Children under 5 years old

• Diagnosed with chronic cholestasis and severe malnutrition

• Parental/guardian informed consent

• Willingness to use a nasogastric tube (NGT) if indicated

• Covered by national health insurance or other insurance

Locations
Other Locations
Indonesia
Faculty of Medicine, University of Indonesia, Jakarta, DKI Jakarta 10430
RECRUITING
Jakarta Pusat
Contact Information
Primary
Tri Faranita, dr, Sp.A
tri.faranita@ui.ac.id
+628126016641
Backup
Klara Yuliarti, Dr. dr, Sp.A(K)
klarayuliarti@yahoo.com
+628129300755
Time Frame
Start Date: 2026-04-06
Estimated Completion Date: 2026-07
Participants
Target number of participants: 15
Treatments
Experimental: Nutrition Therapy Group
Nutrition therapy
Related Therapeutic Areas
Sponsors
Leads: Indonesia University

This content was sourced from clinicaltrials.gov