ChordomaSymptoms, Doctors, Treatments, Advances & More
Learn About Chordoma
View Main Condition: Brain Tumor
A chordoma is a rare type of cancerous tumor that can occur anywhere along the spine, from the base of the skull to the tailbone. Chordomas grow slowly, gradually extending into the bone and soft tissue around them. They often recur after treatment, and in about 40 percent of cases the cancer spreads (metastasizes) to other areas of the body, such as the lungs.
Changes in the TBXT gene have been associated with chordoma. An inherited duplication of the TBXT gene identified in a few families is associated with an increased risk of developing a chordoma. Duplications or increases in activity (expression) of the TBXT gene have also been identified in people with chordoma who have no history of the disorder in their family. In these individuals, the changes occur only in the tumor cells and are not inherited.
Chordomas are rare, occurring in approximately 1 per million individuals each year. Chordomas comprise fewer than 1 percent of tumors affecting the brain and spinal cord.
When development of a chordoma is associated with a duplication of the TBXT gene inherited from a parent, one copy of the altered gene in each cell is sufficient to increase the risk of the disorder, which is an inheritance pattern called autosomal dominant. People with this duplication inherit an increased risk of this condition, not the condition itself.
Jean-paul Wolinsky is a Neurosurgery provider in Chicago, Illinois. Dr. Wolinsky has been practicing medicine for over 28 years and is rated as an Elite provider by MediFind in the treatment of Chordoma. His top areas of expertise are Chordoma, Bone Tumor, Spinal Tumor, Spinal Fusion, and Laminectomy.
Johns Hopkins Outpatient Center
Dr. Gary Gallia's specialty is endoscopic endonasal surgical approaches to skull base pathologies with a focus on neurosurgical oncology. He utilizes the latest techniques in preoperative imaging, computer-guided surgical navigation, intraoperative monitoring, and minimally invasive and Neuroendoscopy approaches in the management of patients with benign and malignant brain tumors, metastatic tumors to the brain, skull base neoplasms, and pituitary tumors. He is the director of the Neurosurgery Skull Base Center and surgical director of the Johns Hopkins Pituitary Center. Dr. Gary Gallia graduated summa cum laude from the Gibbons Scholar MD/PhD program at Jefferson Medical College and Thomas Jefferson University. He completed his general surgery internship at The Johns Hopkins Hospital where he was awarded surgical intern of the year. He then completed his neurological surgery residency and a postdoctoral fellowship in neuro-oncology at The Johns Hopkins Hospital. Following residency, he completed a minimally invasive and endoscopic neurosurgery fellowship with Dr. Charles Teo at the Prince of Wales Private Hospital and Sydney Children's Hospital in Sydney, Australia. Dr. Gallia is rated as an Elite provider by MediFind in the treatment of Chordoma. His top areas of expertise are Olfactory Neuroblastoma, Chordoma, Pituitary Tumor, Awake Craniotomy, and Craniectomy.
Aurora Orthopedics
Nicholas Webber is an Orthopedics provider in Milwaukee, Wisconsin. Dr. Webber is rated as a Distinguished provider by MediFind in the treatment of Chordoma. His top areas of expertise are Osteoarthritis, Osteonecrosis, Rhabdomyosarcoma Embryonal, Hip Replacement, and Knee Replacement.
Summary: The project is planned as a phase II clinical trial with a low level of intervention, for the prospective evaluation of the clinical results of radical or adjuvant treatment by proton therapy in chordomas and chondrosarcomas of the skull base using hypofractionation schemes in 5 fractions, with the aim of consolidating the scientific evidence that exists with high-precision techniques with photons...
Summary: The researchers are doing this study is to find out whether ERAS-601 is a safe and effective treatment that causes few or mild side effects in people with advanced and progressing chordoma.
Published Date: May 01, 2015
Published By: National Institutes of Health