A Technical Framework for Combining Multi-parametric Imaging With Advanced Modelling in Personalized Radiotherapy
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
The study consists in the retrospective and prospective collection of imaging data (along with clinical information related to treatment) of skull-base chordoma patients treated with particle therapy, to derive imaging biomarkers which, integrated with advanced mathematical models, will allow predicting treatment outcome on a multi-scale basis.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients with histologically confirmed diagnosis of chordoma of the skull base
• Particle therapy with curative intent
• Karnofsky Performance status greater than or equal to 60
• Patients with macroscopic disease detectable at pre-radiotherapy imaging
• Patients undergoing PT with standardized treatment procedures
• Patients who have signed the written informed consent for research
Locations
Other Locations
Italy
CNAO
RECRUITING
Pavia
Contact Information
Primary
Alberto Iannalfi, MD
alberto.iannalfi@cnao.it
0382078501
Backup
Cristina Bono, MSc
cristina.bono@cnao.it
0382078613
Time Frame
Start Date: 2022-04-19
Estimated Completion Date: 2025-08-18
Participants
Target number of participants: 35
Treatments
Prospective non-invasive MRI acquisitions are planned to be performed
Prospective non-invasive MRI acquisitions are planned to be performed
retrospective group
patients treated for skull base chordoma with particle therapy
Related Therapeutic Areas
Sponsors
Leads: CNAO National Center of Oncological Hadrontherapy
Collaborators: Dept. of Electronics, Informatics, Bioengineering, Politecnico di Milano, Italy