Chronic Antibody-Mediated Rejection Overview

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Learn About Chronic Antibody-Mediated Rejection

What is the definition of Chronic Antibody-Mediated Rejection?
Chronic antibody-mediated rejection (AMR) is a human leukocyte antigen (HLA) antibody-induced major complication that occurs after solid organ (kidney, lung, pancreas, and intestinal) transplantation that causes ongoing graft injury and graft loss. Chronic antibody-mediated rejection usually occurs more than one year after transplant.
What are the symptoms of Chronic Antibody-Mediated Rejection?
Symptoms of chronic antibody-mediated rejection can depend on the type of organ transplanted; however, the condition is characterized by endothelial cell changes, microvascular inflammation, C4d (complement protein splitting), circulating donor-specific antibodies, fibrosis, graft dysfunction, and probable graft loss. Patient symptoms may also include dyspnea (difficult breathing), cough, fever, malaise, or they may be asymptomatic.
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What are the current treatments for Chronic Antibody-Mediated Rejection?
Currently, there are few therapies that can prevent and reverse chronic antibody-mediated rejection. However, patients are often treated with a range of therapies, such as plasma exchange (PLEX); intravenous immunoglobulin (IVIG); complement inhibitors, such as eculizumab and rituximab; pulse steroids; imlifidase; anti-thymocyte globulin (ATG); or other T-cell-depleting antibodies; the proteasome inhibitor, bortezomib; cyclophosphamide; interleukin-6 inhibitors, and a triple immunosuppressants protocol, which includes mycophenolic acid, tacrolimus, and steroids.
Who are the top Chronic Antibody-Mediated Rejection Local Doctors?
Dr. Adena J. Osband
Transplant Surgery | General Surgery
Dr. Adena J. Osband
Transplant Surgery | General Surgery

University Surgical Associates, Inc.

2 Dudley St, Suite 470, 
Providence, RI 
 (22.6 mi)
401-272-1800
Languages Spoken:
English
See accepted insurances

Adena Osband is a Transplant Surgeon and a General Surgeon in Providence, Rhode Island. Dr. Osband and is rated as an Advanced provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. Her top areas of expertise are Chronic Antibody-Mediated Rejection, End-Stage Renal Disease (ESRD), Febrile Neutropenia, Kidney Transplant, and Simultaneous Pancreas Kidney Transplant.

Dr. Paul E. Morrissey
General Surgery | Transplant Surgery
Dr. Paul E. Morrissey
General Surgery | Transplant Surgery

University Surgical Associates, Inc.

2 Dudley St, Suite 470, 
Providence, RI 
 (22.6 mi)
401-272-1800
Languages Spoken:
English

Paul Morrissey is a General Surgeon and a Transplant Surgeon in Providence, Rhode Island. Dr. Morrissey and is rated as an Advanced provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are End-Stage Renal Disease (ESRD), Polycystic Kidney Disease, Vitamin D Deficiency, Kidney Transplant, and Simultaneous Pancreas Kidney Transplant.

 
 
 
 
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Dr. Shimul A. Shah
Transplant Surgery | General Surgery
Dr. Shimul A. Shah
Transplant Surgery | General Surgery

Massachusetts General Physicians Organization Inc

55 Fruit St, 
Boston, MA 
 (61.5 mi)
617-724-0287
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Shimul Shah is a Transplant Surgeon and a General Surgeon in Boston, Massachusetts. Dr. Shah and is rated as an Experienced provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are Liver Failure, Hepatitis, Cholangiocarcinoma (Bile Duct Cancer), Liver Transplant, and Hepatectomy. Dr. Shah is currently accepting new patients.

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