Chronic Antibody-Mediated Rejection Overview

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Learn About Chronic Antibody-Mediated Rejection

What is the definition of Chronic Antibody-Mediated Rejection?
Chronic antibody-mediated rejection (AMR) is a human leukocyte antigen (HLA) antibody-induced major complication that occurs after solid organ (kidney, lung, pancreas, and intestinal) transplantation that causes ongoing graft injury and graft loss. Chronic antibody-mediated rejection usually occurs more than one year after transplant.
What are the symptoms of Chronic Antibody-Mediated Rejection?
Symptoms of chronic antibody-mediated rejection can depend on the type of organ transplanted; however, the condition is characterized by endothelial cell changes, microvascular inflammation, C4d (complement protein splitting), circulating donor-specific antibodies, fibrosis, graft dysfunction, and probable graft loss. Patient symptoms may also include dyspnea (difficult breathing), cough, fever, malaise, or they may be asymptomatic.
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What are the current treatments for Chronic Antibody-Mediated Rejection?
Currently, there are few therapies that can prevent and reverse chronic antibody-mediated rejection. However, patients are often treated with a range of therapies, such as plasma exchange (PLEX); intravenous immunoglobulin (IVIG); complement inhibitors, such as eculizumab and rituximab; pulse steroids; imlifidase; anti-thymocyte globulin (ATG); or other T-cell-depleting antibodies; the proteasome inhibitor, bortezomib; cyclophosphamide; interleukin-6 inhibitors, and a triple immunosuppressants protocol, which includes mycophenolic acid, tacrolimus, and steroids.
Who are the top Chronic Antibody-Mediated Rejection Local Doctors?
Elite in Chronic Antibody-Mediated Rejection
Takaaki Kobayashi
Elite in Chronic Antibody-Mediated Rejection
Takaaki Kobayashi
Nagakute, JP 

Takaaki Kobayashi practices in Nagakute, Japan. Kobayashi is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. Their top areas of expertise are ABO Incompatibility, Chronic Antibody-Mediated Rejection, Familial Isolated Hyperparathyroidism, Kidney Transplant, and Splenectomy.

Elite in Chronic Antibody-Mediated Rejection
Yoshihiko Watarai
Elite in Chronic Antibody-Mediated Rejection
Yoshihiko Watarai
Okazaki, JP 

Yoshihiko Watarai practices in Okazaki, Japan. Mr. Watarai is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are ABO Incompatibility, Chronic Antibody-Mediated Rejection, Hyperparathyroidism, Kidney Transplant, and Splenectomy.

 
 
 
 
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Distinguished in Chronic Antibody-Mediated Rejection
Dr. Kenneth L. Brayman
Transplant Surgery | General Surgery
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Kenneth L. Brayman
Transplant Surgery | General Surgery

University Of Virginia Physicians Group

1 Hospital Dr, Fl 3, 
Charlottesville, VA 
434-924-1984
Languages Spoken:
English
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Accepting New Patients
Offers Telehealth

Kenneth Brayman is a Transplant Surgeon and a General Surgeon in Charlottesville, Virginia. Dr. Brayman is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. His top areas of expertise are Chronic Antibody-Mediated Rejection, End-Stage Renal Disease (ESRD), Chronic Pancreatitis, Kidney Transplant, and Islet Cell Transplantation. Dr. Brayman is currently accepting new patients.

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