Chronic Antibody-Mediated Rejection
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Chronic Antibody-Mediated Rejection Overview

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Learn About Chronic Antibody-Mediated Rejection

What is the definition of Chronic Antibody-Mediated Rejection?
Chronic antibody-mediated rejection (AMR) is a human leukocyte antigen (HLA) antibody-induced major complication that occurs after solid organ (kidney, lung, pancreas, and intestinal) transplantation that causes ongoing graft injury and graft loss. Chronic antibody-mediated rejection usually occurs more than one year after transplant.
What are the symptoms of Chronic Antibody-Mediated Rejection?
Symptoms of chronic antibody-mediated rejection can depend on the type of organ transplanted; however, the condition is characterized by endothelial cell changes, microvascular inflammation, C4d (complement protein splitting), circulating donor-specific antibodies, fibrosis, graft dysfunction, and probable graft loss. Patient symptoms may also include dyspnea (difficult breathing), cough, fever, malaise, or they may be asymptomatic.
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What are the current treatments for Chronic Antibody-Mediated Rejection?
Currently, there are few therapies that can prevent and reverse chronic antibody-mediated rejection. However, patients are often treated with a range of therapies, such as plasma exchange (PLEX); intravenous immunoglobulin (IVIG); complement inhibitors, such as eculizumab and rituximab; pulse steroids; imlifidase; anti-thymocyte globulin (ATG); or other T-cell-depleting antibodies; the proteasome inhibitor, bortezomib; cyclophosphamide; interleukin-6 inhibitors, and a triple immunosuppressants protocol, which includes mycophenolic acid, tacrolimus, and steroids.
Who are the top Chronic Antibody-Mediated Rejection Local Doctors?
Elite in Chronic Antibody-Mediated Rejection
Yoshihiko Watarai
Elite in Chronic Antibody-Mediated Rejection
Yoshihiko Watarai
Referral may be required
Nagoya, JP 

Yoshihiko Watarai practices practicing medicine in Nagoya, Japan. Mr. Watarai is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. He is also highly rated in 13 other conditions, according to our data. His clinical expertise encompasses ABO Incompatibility, Chronic Antibody-Mediated Rejection, Hyperparathyroidism, Kidney Transplant, and Splenectomy.

Distinguished in Chronic Antibody-Mediated Rejection
Dr. Adam M. Frank
Transplant Surgery | General Surgery
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Adam M. Frank
Transplant Surgery | General Surgery
Referral may be required

Jefferson Nicoletti Kidney Transplant Center

1101 Chestnut Street, Floor 11, 
Philadelphia, PA 
888-855-6649
Languages Spoken:
English
See accepted insurances
Accepting New Patients

Adam Frank is a General Surgeon and a Transplant Surgeon practicing medicine in Philadelphia, Pennsylvania. Dr. Frank is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. He is also highly rated in 6 other conditions, according to our data. His clinical expertise encompasses Chronic Antibody-Mediated Rejection, Hepatitis, End-Stage Renal Disease (ESRD), Kidney Transplant, and Liver Transplant. Dr. Frank is board certified in Surgery. Dr. Frank is currently accepting new patients.

 
 
 
 
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Distinguished in Chronic Antibody-Mediated Rejection
Dr. Derrick A. Christopher
Transplant Surgery
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Derrick A. Christopher
Transplant Surgery
Referral may be required
676 N St Clair St 19th Fl, Arkes Pavilion, 
Chicago, IL 
312-695-8900
Experience:
16+ years
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Derrick Christopher is a Transplant Surgeon practicing medicine in Chicago, Illinois. He has been practicing medicine for over 16 years. Dr. Christopher is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Enlarged Liver, End-Stage Renal Disease (ESRD), Chronic Antibody-Mediated Rejection, Simultaneous Pancreas Kidney Transplant, and Kidney Transplant. Dr. Christopher is board certified in American Board Of Surgery - Surgery (Certified).

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