Chronic Antibody-Mediated Rejection
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Chronic Antibody-Mediated Rejection Overview

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Learn About Chronic Antibody-Mediated Rejection

What is the definition of Chronic Antibody-Mediated Rejection?
Chronic antibody-mediated rejection (AMR) is a human leukocyte antigen (HLA) antibody-induced major complication that occurs after solid organ (kidney, lung, pancreas, and intestinal) transplantation that causes ongoing graft injury and graft loss. Chronic antibody-mediated rejection usually occurs more than one year after transplant.
What are the symptoms of Chronic Antibody-Mediated Rejection?
Symptoms of chronic antibody-mediated rejection can depend on the type of organ transplanted; however, the condition is characterized by endothelial cell changes, microvascular inflammation, C4d (complement protein splitting), circulating donor-specific antibodies, fibrosis, graft dysfunction, and probable graft loss. Patient symptoms may also include dyspnea (difficult breathing), cough, fever, malaise, or they may be asymptomatic.
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What are the current treatments for Chronic Antibody-Mediated Rejection?
Currently, there are few therapies that can prevent and reverse chronic antibody-mediated rejection. However, patients are often treated with a range of therapies, such as plasma exchange (PLEX); intravenous immunoglobulin (IVIG); complement inhibitors, such as eculizumab and rituximab; pulse steroids; imlifidase; anti-thymocyte globulin (ATG); or other T-cell-depleting antibodies; the proteasome inhibitor, bortezomib; cyclophosphamide; interleukin-6 inhibitors, and a triple immunosuppressants protocol, which includes mycophenolic acid, tacrolimus, and steroids.
Who are the top Chronic Antibody-Mediated Rejection Local Doctors?
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Matthew J. Ellis
Transplant Surgery
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Matthew J. Ellis
Transplant Surgery
Referral may be required

Duke Kidney/Pancreas Transplant Clinic - Clinic 2B/2C

40 Duke Medicine Cir, 
Durham, NC 
855-855-6484
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Matthew Ellis is a Transplant Surgeon practicing medicine in Durham, North Carolina. Dr. Ellis is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. He is also highly rated in 3 other conditions, according to our data. His clinical expertise encompasses Chronic Antibody-Mediated Rejection, End-Stage Renal Disease (ESRD), Atypical Hemolytic Uremic Syndrome (aHUS), Fibrolamellar Carcinoma, and Kidney Transplant. Dr. Ellis is board certified in American Board Of Internal Med, Nephrology and American Board Of Internal Med, Internal Medicine . Dr. Ellis is currently accepting new patients.

Distinguished in Chronic Antibody-Mediated Rejection
Dr. Derrick A. Christopher
Transplant Surgery
Distinguished in Chronic Antibody-Mediated Rejection
Dr. Derrick A. Christopher
Transplant Surgery
Referral may be required
676 N St Clair St 19th Fl, Arkes Pavilion, 
Chicago, IL 
312-695-8900
Languages Spoken:
English, Polish, Spanish
See accepted insurances
Accepting New Patients
Offers Telehealth

Derrick Christopher is a Transplant Surgeon practicing medicine in Chicago, Illinois. Dr. Christopher is rated as a Distinguished provider by MediFind in the treatment of Chronic Antibody-Mediated Rejection. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Enlarged Liver, End-Stage Renal Disease (ESRD), Chronic Antibody-Mediated Rejection, Simultaneous Pancreas Kidney Transplant, and Kidney Transplant. Dr. Christopher is board certified in American Board Of Surgery - Surgery (Certified). Dr. Christopher is currently accepting new patients.

 
 
 
 
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Elite in Chronic Antibody-Mediated Rejection
Elite in Chronic Antibody-Mediated Rejection
Referral may be required
Nagakute, JP 

Takaaki Kobayashi practices practicing medicine in Nagakute, Japan. Kobayashi is rated as an Elite expert by MediFind in the treatment of Chronic Antibody-Mediated Rejection. They are also highly rated in 4 other conditions, according to our data. Their clinical expertise encompasses ABO Incompatibility, Chronic Antibody-Mediated Rejection, Milk-Alkali Syndrome, Kidney Transplant, and Splenectomy.

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