Chronic Demyelinizing Neuropathy with IgM Monoclonal
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Chronic Demyelinizing Neuropathy with IgM Monoclonal Overview

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Learn About Chronic Demyelinizing Neuropathy with IgM Monoclonal

What is the definition of Chronic Demyelinizing Neuropathy with IgM Monoclonal?
Chronic demyelinizing neuropathy with IgM (immunoglobin M) monoclonal is a clonal plasma cell disorder characterized by the presence of immunoglobulin M in which an individual experiences progressive damage to the myelin sheath that damages the underlying nerves.
What are the symptoms of Chronic Demyelinizing Neuropathy with IgM Monoclonal?
The main symptom of chronic demyelinizing neuropathy with IgM is peripheral nerve damage that affects motor functions.
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What are the current treatments for Chronic Demyelinizing Neuropathy with IgM Monoclonal?
There is currently no definitive or fully effective treatment for chronic demyelinizing neuropathy with IgM. Treatment for this disease is focused on alleviating symptoms and includes intravenous human immunoglobulin (IVIG), plasma exchange (plasmapheresis), fludarabine, rituximab, and prednisone.
Who are the top Chronic Demyelinizing Neuropathy with IgM Monoclonal Local Doctors?
Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Referral may be required
Milan, IT 

Eduardo Orazio-Nobile practices practicing medicine in Milan, Italy. Mr. Orazio-Nobile is rated as an Elite expert by MediFind in the treatment of Chronic Demyelinizing Neuropathy with IgM Monoclonal. He is also highly rated in 9 other conditions, according to our data. His clinical expertise encompasses Chronic Demyelinizing Neuropathy with IgM Monoclonal, Chronic Polyradiculoneuritis, Chronic Inflammatory Demyelinating Polyneuropathy, and Multifocal Motor Neuropathy.

Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Referral may be required
Centre De Référence Maladies Neuromusculaires Rares Paris Est, 
Paris, FR 

Jean-marc Leger practices practicing medicine in Paris, France. Leger is rated as an Elite expert by MediFind in the treatment of Chronic Demyelinizing Neuropathy with IgM Monoclonal. They are also highly rated in 7 other conditions, according to our data. Their clinical expertise encompasses Chronic Demyelinizing Neuropathy with IgM Monoclonal, Multifocal Motor Neuropathy, Chronic Inflammatory Demyelinating Polyneuropathy, and Chronic Polyradiculoneuritis.

 
 
 
 
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Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Elite in Chronic Demyelinizing Neuropathy with IgM Monoclonal
Referral may be required
Paris, FR 

Karine Viala practices practicing medicine in Paris, France. Ms. Viala is rated as an Elite expert by MediFind in the treatment of Chronic Demyelinizing Neuropathy with IgM Monoclonal. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Chronic Demyelinizing Neuropathy with IgM Monoclonal, Chronic Polyradiculoneuritis, Chronic Inflammatory Demyelinating Polyneuropathy, and Guillain-Barre Syndrome.

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What are the latest Chronic Demyelinizing Neuropathy with IgM Monoclonal Clinical Trials?
Zanubrutinib, a Second Generation BTK Inhibitor, in Anti-MAG Antibody Neuropathy: a Phase II Italian Multicenter Clinical Trial (MAZINGA)
Zanubrutinib, a Second Generation BTK Inhibitor, in Anti-MAG Antibody Neuropathy: a Phase II Italian Multicenter Clinical Trial (MAZINGA)
Enrollment Status: Recruiting
Publish Date: June 10, 2026
Intervention Type: Drug
Study Phase: Phase 2

Summary: The MAZINGA study is a multicenter, open-label, single-arm Phase IIA clinical trial designed to evaluate the efficacy, safety, and tolerability of zanubrutinib in patients with IgM anti-myelin-associated glycoprotein (anti-MAG) antibody-associated demyelinating polyneuropathy. Anti-MAG neuropathy is a rare immune-mediated disorder frequently associated with IgM monoclonal gammopathies, including m...

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