Chronic Erosive Gastritis Overview
Learn About Chronic Erosive Gastritis
Chronic Erosive Gastritis is a long-term condition characterized by inflammation and superficial erosions in the lining of the stomach. Unlike acute gastritis, which develops suddenly and improves quickly, chronic erosive gastritis progresses slowly over months or years. The erosions, which are shallow damaged areas of the stomach lining, can impair the stomach’s ability to protect itself against acid and digestive enzymes. This can cause persistent irritation and discomfort, along with potential complications such as gastrointestinal bleeding, anemia, or even an increased risk of stomach cancer. Early recognition and treatment are important for preventing long-term damage and improving quality of life.
Chronic Erosive Gastritis is a condition marked by ongoing inflammation and shallow erosions of the stomach lining. These erosions are less severe than ulcers but can still weaken the protective barrier of the stomach, making it more susceptible to injury from stomach acid. Over time, repeated irritation leads to persistent inflammation, which can interfere with digestion and increase the risk of complications. Chronic erosive gastritis is usually diagnosed through endoscopy, where the stomach lining appears red, inflamed, and worn away in patches.
Chronic Erosive Gastritis can result from multiple contributing factors. These factors gradually weaken the stomach lining, cause inflammation, and may lead to erosions over time. Understanding the most common causes can help in identifying and reducing risk.
- Long-term NSAID use: Frequent or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen is a leading cause. These drugs disrupt the protective mucus layer of the stomach and increase vulnerability to acid injury.
- Helicobacter pylori infection: This spiral-shaped bacterium infects the stomach lining and is the most common cause of chronic gastritis worldwide. It induces inflammation that leads to erosion over time.
- Alcohol consumption: Excessive or chronic alcohol intake irritates the stomach lining, disrupts mucus production, and increases acid exposure.
- Bile reflux: When bile flows backward from the small intestine into the stomach, it can irritate and damage the stomach lining.
- Autoimmune disorders: Autoimmune gastritis occurs when the body’s immune system mistakenly attacks stomach cells, leading to inflammation and erosion. It often coexists with other autoimmune diseases such as type 1 diabetes or pernicious anemia.
- Chronic stress: Long-term stress does not directly cause gastritis but can worsen inflammation, increase acid production, and delay healing of the stomach lining.
- Radiation therapy: Radiation targeting the abdomen or pelvis can damage the stomach lining and cause chronic erosive changes.
- Crohn’s disease: Although Crohn’s disease primarily affects the intestines, it can also involve the stomach, producing chronic inflammation and erosion.
- Other contributing factors: Smoking, frequent vomiting, consumption of spicy or acidic foods, exposure to corrosive substances, and viral infections (such as cytomegalovirus) can all contribute to erosive gastritis.
Chronic Erosive Gastritis does not develop suddenly but results from repeated irritation and inflammation of the stomach lining over time. It is not contagious and cannot be spread from person to person. Instead, it occurs when the protective mechanisms of the stomach are weakened and acid exposure damages the tissue.
You may be at higher risk if you regularly take NSAIDs, have an H. pylori infection, consume alcohol frequently, live with autoimmune disease, undergo chemotherapy or radiation, or experience bile reflux. Chronic stress and poor lifestyle habits such as smoking can further increase susceptibility. Over time, these factors reduce the stomach’s ability to repair itself, leading to erosions and inflammation that can persist if untreated.
The symptoms of Chronic Erosive Gastritis can range from mild digestive discomfort to severe complications. Some individuals may not experience any symptoms and only discover the condition during a medical exam. Others may have persistent gastrointestinal issues that affect daily life. Recognizing symptoms early can help ensure timely treatment and prevent complications.
- Upper abdominal discomfort or burning pain
- Feeling bloated or full quickly after eating
- Nausea, especially on an empty stomach
- Loss of appetite and indigestion
- Unintentional weight loss due to reduced food intake
- Vomiting blood or material resembling coffee grounds
- Black, tarry stools from gastrointestinal bleeding
- Fatigue caused by blood loss and iron deficiency anemia
- Pale skin, dizziness, or weakness linked to anemia
In some cases, chronic erosive gastritis is asymptomatic and only identified during tests or endoscopy for unrelated issues.
Diagnosis of Chronic Erosive Gastritis requires careful evaluation since its symptoms overlap with other gastrointestinal disorders such as ulcers or acid reflux. Doctors use a combination of history, examination, and tests to confirm the diagnosis and rule out more serious conditions.
- Medical history and physical exam: A doctor reviews symptoms, medication use, alcohol intake, and history of H. pylori or autoimmune conditions. Abdominal tenderness may be detected during the exam.
- Upper endoscopy (EGD): The gold standard for diagnosis, endoscopy allows direct visualization of the stomach lining and collection of biopsies for further testing.
- Biopsy: Tissue samples help identify H. pylori, assess inflammation, and detect precancerous or cancerous changes.
- H. pylori testing: Includes urea breath test, stool antigen test, blood antibody testing, and biopsy during endoscopy.
- Blood tests: Evaluate for anemia, vitamin deficiencies, or markers of inflammation such as ESR and CRP.
- Stool testing: Fecal occult blood tests detect hidden blood, indicating bleeding erosions or ulcers.
- Imaging studies: Ultrasound or CT may be performed to rule out other causes of gastrointestinal symptoms but are not first-line tests.
Treatment aims to reduce stomach acid, promote healing, prevent complications, and address the underlying cause. Management usually involves a combination of medications, lifestyle modifications, and in some cases, procedures.
- Proton pump inhibitors (PPIs): Medications such as omeprazole or pantoprazole suppress stomach acid production, allowing healing of erosions.
- H2 receptor blockers: Less potent than PPIs, drugs like famotidine also reduce acid secretion and may be helpful in mild cases.
- Antacids: Provide short-term relief by neutralizing stomach acid.
- Sucralfate: Forms a protective barrier over damaged tissue, shielding it from acid.
- H. pylori eradication therapy: A combination of antibiotics and PPIs eliminates infection and reduces inflammation.
- Prostaglandin analogs: Misoprostol protects the stomach lining and is especially useful in NSAID-induced gastritis.
- Lifestyle modifications: Reduce NSAID use when possible, avoid alcohol and smoking, eat smaller frequent meals, and avoid spicy or greasy foods. Stress reduction through relaxation techniques, yoga, or counseling may also help.
- Vitamin B12 supplementation: Necessary in autoimmune gastritis where absorption is impaired.
- Endoscopic or surgical intervention: Reserved for severe cases involving active bleeding, ulcers, or suspected malignancy.
Chronic Erosive Gastritis is a persistent inflammatory condition of the stomach lining that can lead to significant discomfort and serious complications if untreated. Common causes include long-term NSAID use, H. pylori infection, alcohol consumption, bile reflux, and autoimmune conditions. Symptoms vary widely, ranging from mild digestive upset to gastrointestinal bleeding and anemia. Diagnosis is typically confirmed with endoscopy and biopsy.
Treatment involves acid-suppressing medications, eradication of H. pylori when present, lifestyle modifications, and in severe cases, endoscopic or surgical procedures. With timely treatment and careful management, most individuals can achieve relief and avoid long-term complications.
- Kuipers, E. J. (1997). Review article: exploring the link between Helicobacter pylori and gastric cancer. Alimentary Pharmacology & Therapeutics, 11(Suppl 1), 121–127.
- Sonnenberg, A. (2013). Review article: historic changes of Helicobacter pylori-associated diseases. Alimentary Pharmacology & Therapeutics, 38(4), 329–342.
- Lanza, F. L., Chan, F. K., & Quigley, E. M. (2009). Guidelines for prevention of NSAID-related ulcer complications. The American Journal of Gastroenterology, 104(3), 728–738.
Advocate Medical Group Gastroenterology
Rogelio Silva is a Gastroenterologist in Oak Lawn, Illinois. Dr. Silva is rated as a Distinguished provider by MediFind in the treatment of Chronic Erosive Gastritis. His top areas of expertise are Angiodysplasia of the Colon, Gastrointestinal Bleeding, Chronic Erosive Gastritis, Gastrectomy, and Gastrostomy.
Advocate Medical Group
Arun Narang is a primary care provider, practicing in Internal Medicine in Mchenry, Illinois. Dr. Narang is rated as a Distinguished provider by MediFind in the treatment of Chronic Erosive Gastritis. His top areas of expertise are Chronic Erosive Gastritis, Chronic Obstructive Pulmonary Disease (COPD), Lung Metastases, Gastrostomy, and Endoscopy.
Peter Malfertheiner practices in Magdeburg, Germany. Mr. Malfertheiner is rated as an Elite expert by MediFind in the treatment of Chronic Erosive Gastritis. His top areas of expertise are Helicobacter Pylori Infection, Gastritis, Chronic Erosive Gastritis, Endoscopy, and Pancreaticoduodenectomy.
Summary: This study aims to evaluate the efficacy of Fexuclue tablets in improving gastrointestinal symptoms based on patient-reported outcomes (PROs), by comparing assessments before and after treatment.
Summary: The aim of this study is to evaluate the efficacy and safety of a quadruple therapy consisting of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate for the first phase eradication of Helicobacter pylori. Assuming that the quadruple therapy of berberine hydrochloride, minocycline, esomeprazole, and colloidal bismuth tartrate is no less effective than the bismuth con...

