Learn About Chronic Familial Neutropenia

What is the definition of Chronic Familial Neutropenia?
Chronic familial neutropenia is a genetic disorder characterized by persistent, lower than normal levels of neutrophils in the blood. Neutrophils are a type of white blood cell that heal infections and repair damaged tissue.
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What are the symptoms of Chronic Familial Neutropenia?
Symptoms of chronic familial neutropenia include inflamed gums (gingivitis), periodontitis (gum disease), recurrent oral ulcerations, early tooth loss, and clubbing of fingers.
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What are the current treatments for Chronic Familial Neutropenia?
While chronic familial neutropenia cannot be cured, treatment is focused on alleviating symptoms. Antibiotics or corticosteroids may be used to fight infection. In some select cases, granulocyte-colony stimulating factors or bone marrow transplant may be used.
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What are the latest Chronic Familial Neutropenia Clinical Trials?
Phase 1/2 Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Abatacept for Treating Chronic Cytopenia in Cytotoxic T-lymphocyte Antigen 4 (CTLA4) Haploinsufficiency

Background: CTLA4 stands for cytotoxic T-lymphocyte antigen-4. It is a protein the body makes naturally to check its immune system from attacking itself. Some people don t produce enough CTLA4 protein, causing problems due to overactive immune system such as big spleens, repeated lung infections, breathing problems, stomach and intestine symptoms as well as inflamed brain and nerve problems. Many have problem...

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A Phase 1b/2, Open-Label, Multicenter Study of Mavorixafor in Patients With Congenital Neutropenia and Chronic Neutropenia Disorders

Summary: This is a 2-part study of mavorixafor in participants diagnosed with chronic neutropenia. The main goal of Part 1 (Phase 1b) is to help researchers learn more about how the investigational medicine, mavorixafor, impacts people living with chronic neutropenia (including congenital, idiopathic, and cyclic). In Part 2 (Phase 2), the safety and tolerability of chronic dosing of mavorixafor will be eva...

What are the Latest Advances for Chronic Familial Neutropenia?
Trientine tetrahydrochloride versus penicillamine for maintenance therapy in Wilson disease (CHELATE): a randomised, open-label, non-inferiority, phase 3 trial.
CML-047 Post Hoc Analysis of Responses to Ponatinib in Patients With Chronic-Phase Chronic Myeloid Leukemia (CP-CML) by Baseline BCR::ABL1 Level and Baseline Mutation Status in the OPTIC Trial.
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CLL-137 SEQUOIA: Results of a Phase 3 Randomized Study of Zanubrutinib Versus Bendamustine + Rituximab (BR) in Patients With Treatment-Naïve (TN) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/ SLL).