Chronic inflammatory demyelinating polyneuropathy (CIDP) is a disorder that involves nerve swelling and irritation (inflammation) that leads to a loss of strength or sensation.
Chronic inflammatory demyelinating polyradiculoneuropathy; Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory polyneuropathy; Guillain-Barré - CIDP
CIDP is one cause of damage to nerves outside the brain or spinal cord (peripheral neuropathy). Polyneuropathy means several nerves are involved. CIDP often affects both sides of the body.
CIDP is caused by an abnormal immune response. CIDP occurs when the immune system attacks the myelin cover of the nerves. For this reason, CIDP is thought to be an autoimmune disease.
Health care providers also consider CIDP as the chronic form of Guillain-Barré syndrome.
The specific triggers of CIDP vary. In many cases, the cause cannot be identified.
CIDP may occur with other conditions, such as:
Symptoms include any of the following:
Other symptoms that can occur with CIDP include:
The goal of treatment is to reverse the attack on the nerves. In some cases, nerves can heal and their function can be restored. In other cases, nerves are badly damaged and cannot heal, so treatment is aimed at preventing the disease from getting worse.
Which treatment is given depends on how severe the symptoms are, among other things. The most aggressive treatment is only given if you have difficulty walking, breathing, or if symptoms don't allow you to care for yourself or work.
Treatments may include:
Eduardo Orazio-Nobile practices in Milan, Italy. Orazio-Nobile is rated as an Elite expert by MediFind in the treatment of Chronic Inflammatory Demyelinating Polyneuropathy. He is also highly rated in 10 other conditions, according to our data. His top areas of expertise are Chronic Polyradiculoneuritis, Chronic Inflammatory Demyelinating Polyneuropathy, Multifocal Motor Neuropathy, and Chronic Demyelinizing Neuropathy with IgM Monoclonal.
Ingemar Merkies practices in Maastricht, Netherlands. Merkies is rated as an Elite expert by MediFind in the treatment of Chronic Inflammatory Demyelinating Polyneuropathy. They are also highly rated in 12 other conditions, according to our data. Their top areas of expertise are Chronic Polyradiculoneuritis, Chronic Inflammatory Demyelinating Polyneuropathy, Erythromelalgia, and Guillain-Barre Syndrome.
David Cornblath is a Neurologist in Baltimore, Maryland. Cornblath has been practicing medicine for over 46 years and is rated as an Elite expert by MediFind in the treatment of Chronic Inflammatory Demyelinating Polyneuropathy. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are Chronic Polyradiculoneuritis, Chronic Inflammatory Demyelinating Polyneuropathy, Guillain-Barre Syndrome, and Peripheral Neuropathy. He is licensed to treat patients in Maryland. Cornblath is currently accepting new patients.
The outcome varies. The disorder may continue long term, or you may have repeated episodes of symptoms. Complete recovery is possible, but permanent loss of nerve function is not uncommon.
Complications of CIDP include:
Call your provider if you have a loss of movement or sensation in any area of the body, especially if your symptoms get worse.
Summary: Antibody-mediated idiopathic inflammatory diseases of the nervous system (also known as autoimmune diseases of the nervous system) are autoimmune diseases in which autoimmune cells and immune molecules attack the nervous system as the main pathogenic mechanism. In the immune response, pathogenic antibodies acting on autoantigens of the nervous system are collectively referred to as autoantibodies ...
Summary: This is the open-label extension study of phase II ARGX-113-1802 to evaluate the long-term safety and efficacy of the subcutaneous formulation of efgartigimod in adults with CIDP. Patients already stabilized on efgartigimod PH20 SC will also have the opportunity to participate in a sub study to explore less frequent dosing of efgartigimod PH20 SC.
Published Date: April 25, 2022
Published By: Joseph V. Campellone, MD, Department of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Katirji B. Disorders of peripheral nerves. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 106.
Smith G, Shy ME. Peripheral neuropathies. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 392.