Nasal High Flow (NHF) in COPD - Effects on Ventilation With Asymmetrical Nasal Cannulas (NHFDuet)
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The aim of this controlled randomized crossover study is to compare the physiological effects of nasal high flow therapy (NHF) with 2 different nasal cannulas in patients with exacerbated chronic obstructive pulmonary disease (ECOPD) and chronic respiratory failure. 20 patients will be treated with NHF therapy (Airvo, Fisher\&Paykel Healthcare, NZ) during wakefulness. Physiological measuremends will take place over three perdiods (visits). One period without NHF, one with NHF via standard cannula (Optiflow M) and one with asymmetrical cannula (Optiflow Duet) in randomised order.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Inpatients with COPD GOLD 3 and 4 in stable phase after acute exacerbation
• Inpatients with COPD GOLD (2, 3 and 4)
• Informed Consent
Locations
Other Locations
Germany
Georg N Nilius
RECRUITING
Essen
Contact Information
Primary
Georg N Nilius, Prof. Dr. med
G.Nilius@kem-med.com
+49 201 174
Backup
Ulrike Domanski
U.Domanski@kem-med.com
+49 0201 174
Time Frame
Start Date: 2023-01-19
Estimated Completion Date: 2024-04-01
Participants
Target number of participants: 20
Treatments
Active_comparator: Nasal High Flow with Optiflow M cannula
Nasal high flow treatment 35L/min with the standard symmetric nasal cannula (Optiflow M)
Active_comparator: Nasal High Flow with Optiflow Duet Cannula
Nasal high flow treatment 35L/min with the asymmetric nasal cannula (Optiflow Duet)
Related Therapeutic Areas
Sponsors
Leads: Kliniken Essen-Mitte
Collaborators: Fisher and Paykel Healthcare