The Physiologic Effects of Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure. A Randomized Crossover Study.

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this randomized crossover physiological study is to evaluate the physiologic effects of asymmetrical nasal cannula and conventional nasal cannula in patients with acute respiratory failure. The main questions it aims to answer are: * Does the asymmetrical high-flow nasal cannula reduce the diaphragm and parasternal intercostal work activity of breathing measured by ultrasound compared to conventional high-flow nasal cannula? * What is the effect of the asymmetrical high-flow nasal cannula on breathing pattern, gas exchange, and hemodynamic variables compared to conventional high-flow nasal cannula? Participants will received asymmetrical high-flow nasal cannula or conventional high-flow nasal cannula at a flow rate of 40 and 60 L/min in a random order.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Age \> 18 years old

• Acute respiratory failure within 7 days of hospital admission?

• Hypoxemia defined by arterial partial pressure of oxygen (PaO2)/FiO2 \< 300 mmHg or SpO2/FiO2 \< 315

• Already supported with HFNC device

Locations
Other Locations
Thailand
Faculty of Medicine Siriraj Hospital
RECRUITING
Bangkok Noi
Contact Information
Primary
Nuttapol Rittayamai, M.D.
nuttapol.rit@mahidol.ac.th
+664197757
Time Frame
Start Date: 2024-01-20
Estimated Completion Date: 2025-05-15
Participants
Target number of participants: 40
Treatments
Experimental: Asymmetrical high-flow nasal cannula
* Asymmetrical nasal cannula (Optiflow+ Duet nasal cannula)~* Airvo-2 (Fisher\&Paykel)
Active_comparator: Conventional high-flow nasal cannula
* Conventional nasal cannula (Optiflow+ nasal cannula)~* Airvo-2 (Fisher\&Paykel)
Sponsors
Leads: Siriraj Hospital

This content was sourced from clinicaltrials.gov