Is Conditioned Pain Modulation Predictive of Clinical Improvement in Patients With Chronic Low Back Pain?

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Conditioned pain modulation (CPM) a measure of the effectiveness of the descending pain pathway and therefore a measure of the body's ability to perform endogenous analgesia. In subjects with normal function of the descending pain pathway, the net-effect during CPM testing is anti-nociceptive, or inhibition of the ascending pain pathway. In those with impaired descending pain pathway function, the response to CPM testing is pro-nociceptive, indicating that the body is unable to inhibit the pain signal, or may even amplify it. There is literature that supports the presence of impaired CPM, and therefore impaired descending pain pathway function, in numerus chronic pain conditions, including low back pain. Impaired descending pain pathway function may be contributing to this chronic pain presentation. This study will give us information on whether a typical physical therapy plan of care is able to improve impaired CPM, and if CPM values are predictive of improvement in physical therapy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 64
Healthy Volunteers: f
View:

• DEERS eligible

• English speaking

• Age 18-64 years

• ODI baseline ≥25%

• NPRS baseline ≥3/10

• Low back pain symptoms greater than 3 months

• Must be able to commit to at least six weeks of physical therapy interventions

Locations
United States
Texas
Brooke Army Medical Center
RECRUITING
Fort Sam Houston
Contact Information
Primary
Kyle R Petrey, DPT
kyle.r.petrey.mil@health.mil
8472742794
Time Frame
Start Date: 2024-09-19
Estimated Completion Date: 2025-07
Participants
Target number of participants: 57
Treatments
Experimental: chronic low back pain
Age 18-64 years with low back pain duration greater than 3 months.
Related Therapeutic Areas
Sponsors
Leads: Brooke Army Medical Center

This content was sourced from clinicaltrials.gov