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Mechanisms of Mindfulness Meditation and Self-Hypnosis for Pain in Older Adults With Chronic Pain

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this study is to better understand how two common psychological treatments for pain work in the brain of older adults living with chronic pain. This study will: 1. evaluate fMRI of adults receiving psychological treatments for chronic pain to determine how these interventions work within older adults, and 2. examine self-report and EEG variables to identify for whom do these psychological interventions work. Adults ages 60 years and older, living with chronic pain for at least 3 months will be randomly assigned to one of three conditions: 1. Mindfulness-Meditation 2. Therapeutic Hypnosis 3. Story Listening

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• be ≥60 years of age;

• have self-reported chronic pain (≥3-months, with pain experienced on ≥ 50% of days);

• endorse an average intensity of pain ≥3 on a 0-10 numerical rating scale (NRS) for most days of the previous 3-months;

• be able to read, speak, and understand English;

• be naïve to meditation and hypnosis:

‣ never received formal training in or attended a mindfulness meditation or therapeutic hypnosis course;

⁃ have not practiced meditation (e.g., mindfulness meditation, Zen, Buddhism, or meditation applications such as certain types of CALM meditation; or therapeutic hypnosis (e.g., hypnosis applications) in the past 6-months;

⁃ \<20-min. practice/week of meditation or therapeutic hypnosis (not described above) over the past 6-months;

• if currently taking analgesic or psychotropic medication, medication must have been stabilized for ≥4-weeks prior to this study and does not anticipate changes in the medication during the study;

• access to a private place with adequate internet reception to support participation in intervention training sessions;

• not currently participating in another clinical trial or interventional study for chronic pain and willing to refrain from participation in any other clinical trial or interventional study for chronic pain during active participation in this study;

• willing, able, and committed to participate in an in-person EEG, and two MRI/fMRI scans; and

⁃ able to use an electronic device (e.g., smart phone, tablet, computer) independently to access email and webpages or have someone available in their home who can help them with initial session set-up and then leave for the treatment sessions.

Locations
United States
Washington
University of Washington
RECRUITING
Seattle
Contact Information
Primary
Rana Salem, MA
rsalem@uw.edu
206-543-0107
Time Frame
Start Date: 2026-03-04
Estimated Completion Date: 2029-08-31
Participants
Target number of participants: 375
Treatments
Experimental: Mindfulness Meditation
Participants will lie flat on their back with their eyes closed and will listen to a recorded Mindfulness Meditation script.
Experimental: Therapeutic Hypnosis
Participants will lie flat on their back with their eyes closed and will listen to a recorded hypnotic script.
Experimental: Story Listening
Participants will lie flat on their back with their eyes closed and will listen to a recorded story from a natural history book.
Related Therapeutic Areas
Sponsors
Collaborators: University of California, San Diego, University of Florida, The University of Queensland, National Institute on Aging (NIA)
Leads: University of Washington

This content was sourced from clinicaltrials.gov