A PiLot ClinicaL TrIal of ParicAlcitol for ChroNiC PancrEatitis
The purpose of this pilot study to examine the feasibility and acceptability of paricalcitol in adults with Chronic Pancreatitis (CP).
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Male or female, aged 18-75 at time of enrollment
• Diagnosis of Chronic Pancreatitis episode is not attributable to gallstones (i.e. suspected or definite biliary etiology), medications, trauma or autoimmune pancreatitis.
• Ability to take oral medication and be willing to adhere to the dosing regimen
• Normal Calcium levels- 8.5 to 10.2 mg/dL
• Normal Phosphate levels- 2.8 to 4.5 mg/dL
• Normal Parathyroid hormone levels- 10 to 65 pg/mL
• For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 1 week after the end of Investigational Product administration
• For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner
• No prior pancreatic surgery
• Pancreatic necrosis, if present, is \<50% (to be verified by radiologist)
• No involvement in any interventional trials currently or within 6 months of enrollment