A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• B/S1 hypertension
• SBP 100-139 average based on 3 office measurements.
• Age 18 or Older
• Previous COA Repair
Locations
United States
Minnesota
Mayo Clinic in Rochester
RECRUITING
Rochester
Contact Information
Primary
ACHD Research Program
RSTACHDRESPRG@mayo.edu
(507) 293-2565
Backup
Alexander Egbe, MBBS, MPH
Egbe.Alexander@mayo.edu
(507) 284-2520
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2028-06-01
Participants
Target number of participants: 120
Treatments
Experimental: Losartan Group
Subjects with Coarctation of Aorta (COA) and high blood pressure will receive Losartan.
Active_comparator: Amlodipine Group
Subjects with Coarctation of Aorta (COA) and high blood pressure will receive Amlodipine.
Placebo_comparator: Placebo Group
Subjects with Coarctation of Aorta (COA) and high blood pressure will receive Placebo.
Related Therapeutic Areas
Sponsors
Leads: Mayo Clinic
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)