Learn About Coats Disease

What is the definition of Coats Disease?
Coats disease is an eye disorder characterized by abnormal development of the blood vessels in the retina (retinal telangiectasia). Most people begin showing symptoms in childhood. Early signs and symptoms vary but may include vision loss, "crossed eyes" (strabismus), and a white mass in the pupil behind the lens of the eye (leukocoria). Over time, Coats disease may also lead to retinal detachment, glaucoma, and clouding of the lens of the eye (cataracts). In most cases, only one eye is affected. Coats disease is not inherited and the underlying cause is not known. It has been theorized that some cases may be due to somatic genetic changes (acquired, not inherited) in the NDP gene.
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What are the alternative names for Coats Disease?
  • Coats disease
  • Leber miliary aneurysm
  • Retinal telangiectasis
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What are the latest Coats Disease Clinical Trials?
Feasibility of Whole-body MRI for Cancer Surveillance in Children and Young People With Ataxia Telangiectasia

Summary: Ataxia Telangiectasia (A-T) is an inherited disorder characterised by cerebellar neurodegeneration, immunodeficiency and respiratory disease. People with A-T have abnormal DNA repair and consequently have an increased risk of cancer. Despite this, current guidelines for management of children and young people with A-T do not include cancer surveillance. Improvements in MRI technology have allowed ...

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The Evaluation of the Safety and Efficacy of Sustained Release Dexamethasone Intracanalicular Insert (DEXTENZA) in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia. (TENDER)

Summary: The Tender Study is a prospective, open-label, single-center, randomized, investigator-initiated clinical study seeks to investigate the safety and efficacy of the DEXTENZA insert in pediatric patients following retinal surgery or laser treatment under anesthesia.

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Coats Disease?
A Novel Approach to Subretinal Fluid Drainage in Coats'-Related Exudative Retinal Detachment.
Coats disease in adolescence and adulthood with preserved vision after laser photocoagulation monotherapy: two case reports.
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Clinical Study of Intravitreal Injection of Anti-VEGF Drugs Combined with Triamcinolone Acetonide in the Treatment of Coats Disease.