Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
This study does not involve randomization or treatment. Eligible patients have colorectal adenocarcinoma with no metastases eligible for curative surgery. A pre operative staging scan must have been completed within 6 weeks prior to surgery. Two x 20ml blood samples will be taken from each patient, one prior to and one during or within 24hrs after surgery. Patients are annually followed up to 3 years.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: f
View:
• Have a biopsy-confirmed colorectal adenocarcinoma
• Is eligible for curative surgery
• Has no metastatic disease on CT scan
• Has completed pre-operative staging scan within six weeks prior to surgery
• Have provided written informed consent to participate in the study
• Be aged 16 years or over
Locations
Other Locations
United Kingdom
St Mary's Hospital (Imperial)
RECRUITING
Hammersmith
Queen Elizabeth the Queen Mother Hospital
RECRUITING
Margate
Royal Marsden Hospital NHS Foundation Trust
RECRUITING
Sutton
Contact Information
Primary
Caroline Martin
c.martin1@imperial.ac.uk
+44 (0) 7749 655 817
Backup
Syvella Ellis
giclinicaltrials@imperial.ac.uk
+44 (0) 7732 315 234
Time Frame
Start Date: 2015-11
Estimated Completion Date: 2029-12
Participants
Target number of participants: 100
Treatments
mrEMVI positive rectal tumours
Patients will be registered whose rectal tumours are mrEMVI positive (i.e. EMVI is present in baseline and post-chemoradiotherapy MRI scans).
mrEMVI negative rectal tumours
Patients registered who were mrEMVI positive at baseline MRI but have become mrEMVI negative post-chemoradiotherapy.
Authors
Gina Brown
Related Therapeutic Areas
Sponsors
Leads: Imperial College London