Common Variable Immune DeficiencySymptoms, Doctors, Treatments, Advances & More
Learn About Common Variable Immune Deficiency
Common variable immune deficiency (CVID) is a disorder that impairs the immune system. People with CVID are highly susceptible to infection from foreign invaders such as bacteria, or more rarely, viruses and often develop recurrent infections, particularly in the lungs, sinuses, and ears. Pneumonia is common in people with CVID. Over time, recurrent infections can lead to chronic lung disease. Affected individuals may also experience infection or inflammation of the gastrointestinal tract, which can cause diarrhea and weight loss. Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID. Immune cells can accumulate in other organs, forming small lumps called granulomas.
The cause in CVID is unknown in approximately 90 percent of cases. It is likely that this condition is caused by both environmental and genetic factors. While the specific environmental factors are unclear, the genetic influences in CVID are believed to be mutations in genes that are involved in the development and function of immune system cells called B cells. B cells are specialized white blood cells that help protect the body against infection. When B cells mature, they produce special proteins called antibodies (also known as immunoglobulins). These proteins attach to foreign particles, marking them for destruction. Mutations in the genes associated with CVID result in dysfunctional B cells that cannot make sufficient amounts of antibodies.
CVID is estimated to affect 1 in 25,000 to 1 in 50,000 people worldwide, although the prevalence can vary across different populations.
Most cases of CVID are sporadic and occur in people with no apparent history of the disorder in their family. These cases probably result from a complex interaction of environmental and genetic factors.
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Sudhir Gupta is an Allergy and Immunologist practicing medicine in Irvine, California. Dr. Gupta is rated as an Elite provider by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 7 other conditions, according to our data. His clinical expertise encompasses Primary Immunodeficiency (PID), Common Variable Immune Deficiency, X-Linked Agammaglobulinemia, and Immunodeficiency with Hyper IgM Type 1. Dr. Gupta is board certified in American Board Of Allergy And Immunology - Allergy And Immunology.
John Hurst practices practicing medicine in London, United Kingdom. Mr. Hurst is rated as an Elite expert by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses Chronic Obstructive Pulmonary Disease (COPD), Common Variable Immune Deficiency, Bronchiectasis, and Interstitial Lung Disease.
Pal Aukrust practices practicing medicine in Oslo, Norway. Mr. Aukrust is rated as an Elite expert by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 27 other conditions, according to our data. His clinical expertise encompasses Common Variable Immune Deficiency, Atherosclerosis, Heart Failure, Heart Transplant, and Hepato-Pancreato-Biliary Surgery.
Summary: The main purpose of this study is to see if IgPro20 can prevent infection in people with multiple myeloma (MM) who have hypogammaglobulinemia from receiving bispecific monoclonal antibodies (BsAbs).
Background: * Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections. Depending on the underlying cause, these infections may involve the entire respiratory tract, resulting in sinus, ear, and lung disease. * Bronchiectasis continues to be a significant ...
Published Date: May 01, 2016
Published By: National Institutes of Health