Learn About Common Variable Immune Deficiency

What is the definition of Common Variable Immune Deficiency?

Common variable immune deficiency (CVID) is a disorder that impairs the immune system. People with CVID are highly susceptible to infection from foreign invaders such as bacteria, or more rarely, viruses and often develop recurrent infections, particularly in the lungs, sinuses, and ears. Pneumonia is common in people with CVID. Over time, recurrent infections can lead to chronic lung disease. Affected individuals may also experience infection or inflammation of the gastrointestinal tract, which can cause diarrhea and weight loss. Abnormal accumulation of immune cells causes enlarged lymph nodes (lymphadenopathy) or an enlarged spleen (splenomegaly) in some people with CVID. Immune cells can accumulate in other organs, forming small lumps called granulomas.

Save information for later
Sign Up
What are the causes of Common Variable Immune Deficiency?

The cause in CVID is unknown in approximately 90 percent of cases. It is likely that this condition is caused by both environmental and genetic factors. While the specific environmental factors are unclear, the genetic influences in CVID are believed to be mutations in genes that are involved in the development and function of immune system cells called B cells. B cells are specialized white blood cells that help protect the body against infection. When B cells mature, they produce special proteins called antibodies (also known as immunoglobulins). These proteins attach to foreign particles, marking them for destruction. Mutations in the genes associated with CVID result in dysfunctional B cells that cannot make sufficient amounts of antibodies.

How prevalent is Common Variable Immune Deficiency?

CVID is estimated to affect 1 in 25,000 to 1 in 50,000 people worldwide, although the prevalence can vary across different populations.

Is Common Variable Immune Deficiency an inherited disorder?

Most cases of CVID are sporadic and occur in people with no apparent history of the disorder in their family. These cases probably result from a complex interaction of environmental and genetic factors.

Who are the top Common Variable Immune Deficiency Local Doctors?
Elite
Highly rated in
9
conditions
Allergy and Immunology
Adolescent Medicine

University of California Health

Uci Medical Center 
Orange, CA 92868

Sudhir Gupta is an Allergy and Immunologist and an Adolescent Medicine doctor in Orange, California. Dr. Gupta has been practicing medicine for over 56 years and is rated as an Elite doctor by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 9 other conditions, according to our data. His top areas of expertise are Primary Immunodeficiency PID, Common Variable Immune Deficiency, X-Linked Agammaglobulinemia, and Immunodeficiency with Hyper IgM Type 1. He is licensed to treat patients in California. Dr. Gupta is currently accepting new patients.

Elite
Highly rated in
12
conditions
Pediatrics
Allergy and Immunology

Cleveland Clinic Health System

Allergy & Immunology Health Services

5915 Landerbrook Dr 
Mayfield Heights, OH 44124

Robert Hostoffer is a Pediatrics specialist and an Allergy and Immunologist in Mayfield Heights, Ohio. Dr. Hostoffer has been practicing medicine for over 37 years and is rated as an Elite doctor by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 12 other conditions, according to our data. His top areas of expertise are Common Variable Immune Deficiency, Primary Immunodeficiency PID, Anaphylaxis, and Hives. He is licensed to treat patients in Ohio. Dr. Hostoffer is currently accepting new patients.

 
 
 
 
Learn about our expert tiers
Learn more
Elite
Highly rated in
1
conditions
Pediatrics
Pediatric Allergy and Immunology

University of Utah Health

University Hospital

50 N Medical Dr 
Salt Lake City, UT 84132

Harry Hill is a Pediatrics specialist and a Pediatric Allergy and Immunologist in Salt Lake City, Utah. Dr. Hill has been practicing medicine for over 56 years and is rated as an Elite doctor by MediFind in the treatment of Common Variable Immune Deficiency. He is also highly rated in 1 other condition, according to our data. His top areas of expertise are Common Variable Immune Deficiency, Smoldering Multiple Myeloma, X-Linked Agammaglobulinemia, and Chronic Granulomatous Disease. He is licensed to treat patients in Utah. Dr. Hill is currently accepting new patients.

What are the latest Common Variable Immune Deficiency Clinical Trials?
PEDS024, Phase I/II Feasibility Study of Busulfan Fludarabine and Thiotepa Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation (HSCT) for Children With Non-Malignant Disorders
Match to trials
Find the right clinical trials for you in under a minute
Get started
Vaccine-induced SARS-CoV-2-specific T Cell Responses in Patients With Primary Immune Deficiency Disease
Who are the sources who wrote this article ?

Published Date:updated Last, May

Published By: National Institutes of Health

What are the Latest Advances for Common Variable Immune Deficiency?
Vulnerability to Meningococcal Disease in Immunodeficiency Due to a Novel Pathogenic Missense Variant in NFKB1.
Evaluation of MicroRNA-125b-5p and Transcription Factors BLIMP1 and IRF4 Expression in Unsolved Common Variable Immunodeficiency Patients.
Tired of the same old research?
Check Latest Advances
Pulmonary Radiological Manifestations of Humoral and Combined Immunodeficiencies in a Tertiary Pediatric Center.