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Pilot Study on the Correlation Between Accelerations Experienced During Matches by Professional Rugby Players and a Profile of Salivary Biomarkers Identified in the Literature as Related to Concussion.

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Concussion, or mild traumatic brain injury, accounts for 85% of brain injuries and is common in both professional and amateur sports. It results from kinetic impacts causing a temporary disruption of brain function, often without visible abnormalities on imaging, making diagnosis difficult. The majority of concussions remain undetected, without specific management. To facilitate detection, the development of reliable salivary BMs is essential, as they offer a non-invasive, rapid, and simple method for early identification of biological changes related to concussions.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 19
Maximum Age: 20
Healthy Volunteers: t
View:

• Male subject

• Subject aged between 19 and 20 years

• Subject willing to follow the study procedures

• Subject capable of understanding the purpose, nature, and methodology of the study

• Subject affiliated with a French social security scheme or a beneficiary of such a scheme

• Subject who has signed the non-opposition to participation in the research

• Subject who has signed the informed consent for salivary micro-RNA analysis

• Subject selected in the French under-20 rugby team (U20).

Locations
Other Locations
France
Sys2Diag - Umr9005 Cnrs/Alcen
RECRUITING
Montpellier
Contact Information
Primary
Wendpouiré A OUEDRAOGO, MSc
alimata.ouedraogo@sys2diag.cnrs.fr
+33 (0) 467 047 481
Time Frame
Start Date: 2025-01-22
Estimated Completion Date: 2028-01-21
Participants
Target number of participants: 66
Treatments
U20
The saliva of 66 professional rugby players from the French U20 team will be analysed and the variations in biomarkers of interest (identified as related to concussion) will be mesured in order to analyze the correlations of these measurements with those obtained during the same matches by an instrumented mouthguard measuring accelerations.
Related Therapeutic Areas
Sponsors
Leads: Sys2Diag
Collaborators: Centre National de la Recherche Scientifique, France

This content was sourced from clinicaltrials.gov