What is the definition of Congenital Herpes Simplex?

Congenital herpes simplex is when an infant is born infected with the herpes simplex virus (HSV). Herpes simplex virus 2 (HSV-2) is a contagious sexually transmitted disease that can infect a fetus while in the uterus or during vaginal delivery.

What are the symptoms for Congenital Herpes Simplex?

Symptoms of congenital herpes simplex may include persistent fever, vesicles (fluid-filled blisters) on the skin and mucous membranes, sepsis, low body temperature, irritability, lethargy, respiratory distress, shallow or abnormal breathing (apnea), abdominal distention, enlarged liver, fluid in the abdomen (ascites), conjunctivitis (eye inflammation), yellowing of skin and whites of eyes (jaundice), seizures, and coma.

What are the current treatments for Congenital Herpes Simplex?

While there is no cure for congenital herpes simplex, treatment includes intravenous administration of the antiviral medication, acyclovir, followed by oral acyclovir suppressive therapy. Infants with eyes affected by congenital herpes simplex are additionally treated with topical 1% trifluridine, 0.1% iododeoxyuridine, or 0.15% ganciclovir.

There are no recent clinical trials available for this condition. Please check back because new trials are being conducted frequently.