Congenital HyperinsulinismSymptoms, Doctors, Treatments, Advances & More
Congenital Hyperinsulinism Overview
Learn About Congenital Hyperinsulinism
Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin. Insulin is a hormone that helps control levels of blood glucose, also called blood sugar. People with this condition have frequent episodes of low blood glucose (hypoglycemia). In infants and young children, these episodes are characterized by a lack of energy (lethargy), irritability, or difficulty feeding. Repeated episodes of low blood glucose increase the risk for serious complications such as breathing difficulties, seizures, intellectual disability, vision loss, brain damage, and coma.
Congenital hyperinsulinism is caused by mutations in genes that regulate the release (secretion) of insulin, which is produced by beta cells in the pancreas. Insulin clears excess glucose from the bloodstream by passing glucose into cells to be used as energy.
Congenital hyperinsulinism affects approximately 1 in 50,000 newborns. This condition is more common in certain populations, affecting up to 1 in 2,500 newborns.
Congenital hyperinsulinism can have different inheritance patterns, usually depending on the form of the condition. At least two forms of the condition have been identified. The most common form is the diffuse form, which occurs when all of the beta cells in the pancreas secrete too much insulin. The focal form of congenital hyperinsulinism occurs when only some of the beta cells over-secrete insulin.
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Charles Stanley is a Pediatric Endocrinologist practicing medicine in Philadelphia, Pennsylvania. Dr. Stanley is rated as an Elite provider by MediFind in the treatment of Congenital Hyperinsulinism. He is also highly rated in 4 other conditions, according to our data. His clinical expertise encompasses Newborn Low Blood Sugar, Congenital Hyperinsulinism, Low Blood Sugar, Cerebral Hypoxia, and Pancreatectomy.
Sarah Flanagan practices practicing medicine in Exeter, United Kingdom. Ms. Flanagan is rated as an Elite expert by MediFind in the treatment of Congenital Hyperinsulinism. She is also highly rated in 22 other conditions, according to our data. Her clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Transient Neonatal Diabetes Mellitus, Newborn Low Blood Sugar, and Pancreatectomy.
Senthil Senniappan practices practicing medicine in Liverpool, United Kingdom. Senniappan is rated as an Elite expert by MediFind in the treatment of Congenital Hyperinsulinism. They are also highly rated in 25 other conditions, according to our data. Their clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Obesity in Children, Pancreatectomy, and Hormone Replacement Therapy (HRT).
Summary: A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: 1. Pediatric patients (less than 18 years old) with congenital hyperinsulinism. 2. Pediatric patients (less than 18 years old) with neuroblastoma. 3. Pediatric (less than 18 years old) or Adult patients (18 or older) with known or clinically suspected neuroendo...
Summary: This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners, and whether it provides benefits in this regard similar to water.
Published Date: January 01, 2014
Published By: National Institutes of Health