Congenital HyperinsulinismSymptoms, Doctors, Treatments, Advances & More
Congenital Hyperinsulinism Overview
Learn About Congenital Hyperinsulinism
Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin. Insulin is a hormone that helps control levels of blood glucose, also called blood sugar. People with this condition have frequent episodes of low blood glucose (hypoglycemia). In infants and young children, these episodes are characterized by a lack of energy (lethargy), irritability, or difficulty feeding. Repeated episodes of low blood glucose increase the risk for serious complications such as breathing difficulties, seizures, intellectual disability, vision loss, brain damage, and coma.
Congenital hyperinsulinism is caused by mutations in genes that regulate the release (secretion) of insulin, which is produced by beta cells in the pancreas. Insulin clears excess glucose from the bloodstream by passing glucose into cells to be used as energy.
Congenital hyperinsulinism affects approximately 1 in 50,000 newborns. This condition is more common in certain populations, affecting up to 1 in 2,500 newborns.
Congenital hyperinsulinism can have different inheritance patterns, usually depending on the form of the condition. At least two forms of the condition have been identified. The most common form is the diffuse form, which occurs when all of the beta cells in the pancreas secrete too much insulin. The focal form of congenital hyperinsulinism occurs when only some of the beta cells over-secrete insulin.
Sarah Flanagan practices practicing medicine in Exeter, United Kingdom. Ms. Flanagan is rated as an Elite expert by MediFind in the treatment of Congenital Hyperinsulinism. She is also highly rated in 22 other conditions, according to our data. Her clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Transient Neonatal Diabetes Mellitus, Newborn Low Blood Sugar, and Pancreatectomy.
Great Ormond Street Hospital For Children NHS Foundation Trust
Antonia Dastamani practices practicing medicine in London, United Kingdom. Ms. Dastamani is rated as an Elite expert by MediFind in the treatment of Congenital Hyperinsulinism. She is also highly rated in 4 other conditions, according to our data. Her clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Newborn Low Blood Sugar, Pancreatectomy, and Gastrostomy.
Senthil Senniappan practices practicing medicine in Liverpool, United Kingdom. Senniappan is rated as an Elite expert by MediFind in the treatment of Congenital Hyperinsulinism. They are also highly rated in 25 other conditions, according to our data. Their clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Obesity in Children, Pancreatectomy, and Hormone Replacement Therapy (HRT).
Summary: The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body composition, and cardiometabolic health. The main questions it aims to answer are: * Do children with and without ASD differ in cardiorespiratory fitness and handgrip strength...
Summary: The goal of this clinical trial is to test the ability of a home-based parental nutrition intervention to improve diet quality in preschool aged children within low-income, Latinx/Hispanic families. The main questions it aims to answer are: * Does this enhanced intervention change children's diet quality? * Does this enhanced intervention change parental feeding practices? * Does this enhanced int...
Published Date: January 01, 2014
Published By: National Institutes of Health