Congenital HyperinsulinismSymptoms, Doctors, Treatments, Advances & More
Congenital Hyperinsulinism Overview
Learn About Congenital Hyperinsulinism
Congenital hyperinsulinism is a condition that causes individuals to have abnormally high levels of insulin. Insulin is a hormone that helps control levels of blood glucose, also called blood sugar. People with this condition have frequent episodes of low blood glucose (hypoglycemia). In infants and young children, these episodes are characterized by a lack of energy (lethargy), irritability, or difficulty feeding. Repeated episodes of low blood glucose increase the risk for serious complications such as breathing difficulties, seizures, intellectual disability, vision loss, brain damage, and coma.
Congenital hyperinsulinism is caused by mutations in genes that regulate the release (secretion) of insulin, which is produced by beta cells in the pancreas. Insulin clears excess glucose from the bloodstream by passing glucose into cells to be used as energy.
Congenital hyperinsulinism affects approximately 1 in 50,000 newborns. This condition is more common in certain populations, affecting up to 1 in 2,500 newborns.
Congenital hyperinsulinism can have different inheritance patterns, usually depending on the form of the condition. At least two forms of the condition have been identified. The most common form is the diffuse form, which occurs when all of the beta cells in the pancreas secrete too much insulin. The focal form of congenital hyperinsulinism occurs when only some of the beta cells over-secrete insulin.
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Paul Thornton is a Pediatric Endocrinologist practicing medicine in Fort Worth, Texas. Dr. Thornton is rated as an Elite provider by MediFind in the treatment of Congenital Hyperinsulinism. He is also highly rated in 13 other conditions, according to our data. His clinical expertise encompasses Congenital Hyperinsulinism, Newborn Low Blood Sugar, Low Blood Sugar, Pancreatectomy, and Hormone Replacement Therapy (HRT).
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Charles Stanley is a Pediatric Endocrinologist practicing medicine in Philadelphia, Pennsylvania. Dr. Stanley is rated as an Elite provider by MediFind in the treatment of Congenital Hyperinsulinism. He is also highly rated in 5 other conditions, according to our data. His clinical expertise encompasses Newborn Low Blood Sugar, Low Blood Sugar, Congenital Hyperinsulinism, Gigantism, and Pancreatectomy.
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Katherine Lord is a Pediatric Endocrinologist practicing medicine in Philadelphia, Pennsylvania. Dr. Lord is rated as an Elite provider by MediFind in the treatment of Congenital Hyperinsulinism. She is also highly rated in 7 other conditions, according to our data. Her clinical expertise encompasses Congenital Hyperinsulinism, Low Blood Sugar, Newborn Low Blood Sugar, Sotos Syndrome, and Pancreatectomy.
Summary: This is a multi-centre, prospective, randomized, open-label controlled trial designed to evaluate the effectiveness of a flexible digital insulin dose calculator in children under 12 years of age with Type 1 Diabetes Mellitus (T1DM) managed with multiple daily injections (MDI). Participants will be stratified by continuous glucose monitoring (CGM) use and baseline HbA1c, and randomised to receive ...
Summary: The goal of this project is to determine the role of FDOPA/PET as a pre-operative diagnostic imaging procedure for differentiating focal and diffuse forms of congenital hyperinsulinism and locating focal lesions in the pancreas to guide surgical resection.
Published Date: January 01, 2014
Published By: National Institutes of Health