Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 10
Maximum Age: 70
Healthy Volunteers: t
View:
• Age 10-70 years
• Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
• Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Locations
United States
Pennsylvania
Childrens Hospital of Philadelphia
NOT_YET_RECRUITING
Philadelphia
University of Pennsylvania
RECRUITING
Philadelphia
Contact Information
Primary
Jessica R Wilson, MD, MS
jessica.wilson3@uphs.upenn.edu
215 898-3389
Backup
Esther Oyerinde
esther.oyerinde@pennmedicine.upenn.edu
Time Frame
Start Date: 2019-06-17
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 100
Treatments
Other: Phenotyping
All participants will undergo a four-hour frequently sampled oral glucose tolerance test in which they will ingest a 75g glucose beverage (intervention) within five minutes and have samples collected at baseline and for four hours after.~They will also undergo a whole body DXA (intervention) during the study day.
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania