Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA. Patients with ANOCA and without diabetes will undergo invasive coronary microvascular assessment through coronary angiography and insulin resistance assessment through hyperinsulinemic-euglycemic clamp test. Patients enrolled in the study will be followed for a period of 2 years to monitor their clinical status.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Aged over 18 years.
• Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography
• Willing and able to give informed consent for participation in the study
Locations
Other Locations
Italy
Azienda Ospedaliera Universitaria di Verona
RECRUITING
Verona
Contact Information
Primary
Natascia Antonioli
studi.clinici.cardiologia@aovr.veneto.it
0039 0458122320
Time Frame
Start Date: 2024-06-24
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 40
Treatments
Experimental: Non-diabetic patients with ANOCA
* Thermodilution based assessment of coronary microcirculation with the derivation of CFR and IMR~* Hyperinsulinemic euglycemic clamp for insulin resistance assessment
Related Therapeutic Areas
Sponsors
Leads: Azienda Ospedaliera Universitaria Integrata Verona