Learn About Cortical Dysplasia

What is the definition of Cortical Dysplasia?
Cortical dysplasia is a condition present at birth (congenital) that occurs when the neurons in the top layer of the brain (cortex) develop abnormally. This causes the neurons to fire abnormally, causing seizures. Other causes of cortical dysplasia may include genetic disorders or brain injuries. Cortical dysplasia is the most common cause of epilepsy (seizures). The most common type of cortical dysplasia is focal cortical dysplasia (FCD), which is categorized into three types: Type 1 focal cortical dysplasia causes seizures that do not appear until adulthood, and usually involves the brain’s temporal lobe. Type II focal cortical dysplasia is found more frequently in children, involves the brain’s temporal and frontal lobes, and is more severe. Type III focal cortical dysplasia involves damage to another part of the brain, possibly from an early brain injury, in addition to Type 1 or Type II.
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What are the symptoms of Cortical Dysplasia?
Symptoms of cortical dysplasia include seizures, learning disabilities, and developmental delays.
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What are the current treatments for Cortical Dysplasia?
Treatment for cortical dysplasia is mainly focused on controlling the seizures and may include medications (antiepileptics) and a ketogenic diet. For seizures that cannot be controlled with medications or diet (intractable), brain surgery may recommended. If brain surgery is not an option, then treatment with vagal nerve stimulation (VNS) may be considered.
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What are the latest Cortical Dysplasia Clinical Trials?
Cutaneous Tumorigenesis in Patients With Tuberous Sclerosis

Summary: Tuberous sclerosis is a rare, hereditary disease in which patients develop multiple tumors. Although not cancerous, the tumors can affect various organs, including the heart, lungs, kidneys, skin, and central nervous system, with serious medical consequences. The severity of disease varies greatly among patients, from barely detectable to fatal. This study will investigate what causes skin tumors ...

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Study of New Potential Biomarkers of Lymphangioleiomyomatosis: Determination of Cathepsin K, Cystatin C, Collagen Telopeptides and Chondroitin Sulfates

Summary: This is a physiopathological case-control, non-interventional, monocentric study of adult patients with lymphangioleiomyomatosis. The controls are patients followed in neurology at the CHU of Tours for a tuberous sclerosis complex without lymphangioleiomyomatosis, the healthy volunteers are women with neither pulmonary nor renal pathology and recruited at the clinical investigation centre of the C...

What are the Latest Advances for Cortical Dysplasia?
Characterization and management of facial angiofibroma related to tuberous sclerosis complex in the United States: retrospective analysis of the natural history database.
Tuberous sclerosis complex with skin lesions as the initial presentation: A case report and multidisciplinary discussion.
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Cannabidiol for the treatment of refractory epilepsy in children: a critical review of the literature.