Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Long COVID is a complex condition that affects approximately 1.4 million Canadians following SARS-CoV-2 infection. Fatigue is the most common symptom of Long COVID. This feasibility trial will evaluate a new rehabilitation program called COVIDEx for treating fatigue after COVID-19, and compare its effectiveness to the standard treatment currently used. The experimental treatment group will receive an 8-week multi-modal rehabilitation program with two 50-minute sessions per week. 60 participants will be recruited, randomly assigned to the COVIDEx program or standard of care (SoC) and followed for 24 weeks.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults of at least 18 years of age

• Able to provide informed consent

• Can speak and understand English

• Documented history of SARS-CoV-2 infection (positive PCR/antigen test during acute illness or clinical diagnosis by physician during or after the acute illness)

• Fatigue symptoms within 3 months of COVID-19 infection, lasting at least 2 months

• Fatigue symptoms cannot be explained by an alternative diagnosis

• Fatigue symptoms may be new onset following initial recovery from an acute COVID-19 infection or persist from the initial illness

• Fatigue symptoms may have an episodic nature, fluctuate or relapse over time

• Minimal functional capability: able to walk 10-15 minutes and be recovered within 30-60 minutes or without significant post-exertional malaise (PEM)

• Has applicable technology to access Microsoft Teams and Webex (i.e., computer, laptop, tablet)

Locations
Other Locations
Canada
Parkwood Hospital - St. Joseph's Health Care London
RECRUITING
London
Contact Information
Primary
Nicole Billias, BPH, CPT
Nicole.Billias@sjhc.london.on.ca
519-646-6100
Backup
Arden Lawson, BMSc
Arden.Lawson@sjhc.london.on.ca
519-646-6100
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2026-04-01
Participants
Target number of participants: 60
Treatments
Experimental: COVIDEx
This group will receive two 50-minute rehabilitation sessions per week for 8 weeks.
No_intervention: Standard of Care
This group will receive standard of care (no intervention) for the 8-week intervention period.
Related Therapeutic Areas
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR), Western University, Canada
Leads: Lawson Research Institute of St. Joseph's

This content was sourced from clinicaltrials.gov