Learn About Long Haul COVID

View Main Condition: COVID-19

What is the definition of Long Haul COVID?
Post-COVID-19 (coronavirus) syndrome, also known as “long-COVID-19” or “long-haulers,” describes the condition of experiencing lingering symptoms after COVID-19 infection that can persist for weeks or months and/or become long-term health problems. Affecting only an estimated 10% of patients who have had a COVID-19 infection, patients with Post-COVID-19 syndrome test negative for the virus; however, they continue to experience symptoms believed to be caused by lingering organ damage after a COVID-19 infection.
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What are the symptoms of Long Haul COVID?
The most common symptoms of Post-COVID syndrome may include fatigue, shortness of breath, cough, joint pain, and chest pain. Long-term symptoms may include muscle aches, headache, rapid heartbeat, difficulty breathing, loss of taste and/or smell, problems with memory, concentration, or sleep, depression and anxiety, rash, and hair loss. Patients who have suffered organ (lungs, heart, brain) damage from a COVID-19 infection may have an increased risk of long-term health problems, such as difficulty breathing and other pulmonary function disorders, heart failure or other complications, such as myocarditis (heart inflammation) and ventricular dysfunction, difficulty swallowing, acute kidney injury, seizures, strokes, Guillain-Barre syndrome (temporary paralysis), as well as an increased risk of Alzheimer’s disease and Parkinson’s disease. Additional long-term health problems associated with Post-COVID-19 syndrome include abnormal blood clotting that can damage blood vessels, the liver, and kidneys. Patients who experienced severe COVID-19 symptoms requiring mechanical ventilation treatment in the intensive care unit (ICU) may have an increased risk of developing post-traumatic stress syndrome (PTSD), while other patients may develop chronic fatigue syndrome and mood disorders, such as depression and anxiety.
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What are the current treatments for Long Haul COVID?
Currently, there is no definitive treatment for Post-COVID-19 syndrome, while research is ongoing. However, Post-COVID-19 care centers staffed with multidisciplinary teams that focus on rehabilitation and symptom treatment are rapidly opening across the U.S. to provide COVID-19 aftercare to patients affected by Post-COVID-19 syndrome.
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What are the latest Long Haul COVID Clinical Trials?
A Prospective Observational Study in the Context of an Internal Medicine Clinic for Naturopathy and Integrative Medicine

Summary: The observational study aims to investigate the extent to which a two-week stay in an internal medicine clinic for integrative medicine and naturopathy results in an improvement of complaints, impairments, quality of life, anxiety/depressiveness, stress perception and well-being in chronic gastroenterological patients and chronic rheumatological/pain patients. In addition, previous experiences wit...

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Randomized, Placebo-controlled Parallel Group Clinical Trial of Nicotinamide Riboside to Evaluate NAD+ Levels in Individuals With Persistent Cognitive and Physical Symptoms After COVID-19 Illness (Long-COVID)

Summary: The study will assess whether Niagen, a safe dietary supplement, improves recovery of COVID-19 related symptoms in individuals who were infected at least 2 months prior to study entry (Long-COVID Long-haulers). 60% of participants will receive Niagen and 40% will receive PBO. Outcomes will consist of standardized cognitive, neuropsychiatric, physical, functional and biomarker assessments.

What are the Latest Advances for Long Haul COVID?
Can exercise attenuate the negative effects of long COVID syndrome on brain health?
Possible Clinical and Pharmacogenetic Predictors of the Efficacy and Safety of Carbamazepine in Post-COVID-19 Depression.
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Alleviation of Post-COVID-19 Cognitive Deficits by Treatment with EGb 761®: A Case Series.