Cowden Syndrome Overview
Learn About Cowden Syndrome
Cowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.
Changes in the PTEN, KLLN, or WWP1 gene are most commonly identified in people with Cowden syndrome or Cowden-like syndrome.
Although the exact prevalence of Cowden syndrome is unknown, researchers estimate that it affects about 1 in 200,000 people.
Cowden syndrome and Cowden-like syndrome are inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the condition and increase the risk of developing cancer. In some cases, an affected person inherits the mutation from one affected parent. Other cases may result from new mutations in the gene. These cases occur in people with no history of the disorder in their family.
Wake Forest University Health Sciences
Adrian Laxton is a Neurosurgery provider in Winston Salem, North Carolina. Dr. Laxton and is rated as an Experienced provider by MediFind in the treatment of Cowden Syndrome. His top areas of expertise are Trigeminal Neuralgia, Neuralgia, Meningioma, Deep Brain Stimulation, and Gamma Knife Radiosurgery. Dr. Laxton is currently accepting new patients.
Duke Health Integrated Practice Inc
Allan Friedman is a Neurosurgery provider in Durham, North Carolina. Dr. Friedman and is rated as an Experienced provider by MediFind in the treatment of Cowden Syndrome. His top areas of expertise are Astrocytoma, Glioma, Glioblastoma, Awake Craniotomy, and Laminectomy. Dr. Friedman is currently accepting new patients.
Paul Marcom is a Hematologist Oncology provider in Durham, North Carolina. Dr. Marcom and is rated as an Experienced provider by MediFind in the treatment of Cowden Syndrome. His top areas of expertise are Breast Cancer, Paget Disease of the Breast, Breast Cancer in Men, and Angiosarcoma.
Summary: The purpose of this study is to evaluate the effectiveness of an adapted, telehealth functional behavioral therapy (FBTsIDD) specifically focused on promoting appropriate communication and behavioral strategies in individuals with syndromic intellectual and developmental disorders. Participants will be asked to complete virtual study assessments at intake and then on a monthly basis for the durati...
Summary: This is a multicentric, observational, retrospective and prospective study, aiming to estimate the risk of cancer occurrence in subjects carrying a PTEN mutation, based on the constitution of a national cohort.
Published Date: March 03, 2021
Published By: National Institutes of Health