What is the definition of Craniopharyngioma?

A craniopharyngioma is a noncancerous (benign) tumor that develops at the base of the brain near the pituitary gland.

What are the causes for Craniopharyngioma?

The exact cause of the tumor is unknown.

This tumor most commonly affects children between 5 to 10 years of age. Adults can sometimes be affected. Boys and girls are equally likely to develop this tumor.

What are the symptoms for Craniopharyngioma?

Craniopharyngioma causes symptoms by:

  • Increasing pressure on the brain, usually from hydrocephalus
  • Disrupting hormone production by the pituitary gland
  • Pressure or damage to the optic nerve

Increased pressure on the brain can cause:

  • Headache
  • Nausea
  • Vomiting (especially in the morning)

Damage to the pituitary gland causes hormone imbalances that can lead to excessive thirst and urination, and slow growth.

When the optic nerve is damaged by the tumor, vision problems develop. These defects are often permanent. They may get worse after surgery to remove the tumor.

Behavioral and learning problems may be present.

What are the current treatments for Craniopharyngioma?

The goal of the treatment is to relieve symptoms. Usually, surgery has been the main treatment for craniopharyngioma. However, radiation treatment instead of surgery or along with a smaller surgery may be the best choice for some people.

In tumors that cannot be removed completely with surgery alone, radiation therapy is used. If the tumor has a classic appearance on CT scan, a biopsy may not be needed if treatment with radiation alone is planned.

Stereotactic radiosurgery is performed at some medical centers.

This tumor is best treated at a center with experience in treating craniopharyngiomas.

What is the outlook (prognosis) for Craniopharyngioma?

In general, the outlook is good. There is an 80% to 90% chance of a cure if the tumor can be completely removed with surgery or treated with high doses of radiation. If the tumor returns, it will most often come back within the first 2 years after surgery.

Outlook depends on several factors, including:

  • Whether the tumor can be completely removed
  • Which nervous system problems and hormonal imbalances the tumor and treatment cause

Most of the problems with hormones and vision do not improve with treatment. Sometimes, the treatment may even make them worse.

What are the possible complications for Craniopharyngioma?

There may be long-term hormone, vision, and nervous system problems after craniopharyngioma is treated.

When the tumor is not completely removed, the condition may return.

When should I contact a medical professional for Craniopharyngioma?

Call your provider for the following symptoms:

  • Headache, nausea, vomiting, or balance problems (signs of increased pressure on the brain)
  • Increased thirst and urination
  • Poor growth in a child
  • Vision changes
Endocrine

REFERENCES

Styne DM. Physiology and disorders of puberty. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 26.

Suh JH, Chao ST, Murphy ES, Recinos PF. Pituitary tumors and craniopharyngiomas. In: Tepper JE, Foote RL, Michalski JM, eds. Gunderson & Tepper's Clinical Radiation Oncology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 34.

Zaky W, Ater JL, Khatua S. Brain tumors in childhood. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 524.

  • Condition: Diseases of the Clival Region
  • Journal: Acta medica academica
  • Treatment Used: Endoscopic Endonasal Approach
  • Number of Patients: 14
  • Published —
This study determine the safety and outcome of endoscopic endonasal approach to the clival region.
  • Condition: Pediatric Brain Tumors
  • Journal: Neurosurgical focus
  • Treatment Used: Endoscope-Assisted Microsurgery
  • Number of Patients: 106
  • Published —
This study tested the safety and efficacy of using endoscope-assisted microsurgery to treat patients with pediatric brain tumors.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug, Procedure, Device
  • Participants: 39
  • Start Date: April 2021
A Phase 2 Study of Fluorescence Detection of Adult Primary Central Nervous System Tumors in Subjects Receiving Tozuleristide and Imaged With the Canvas System
Clinical Trial
  • Status: Recruiting
  • Participants: 10000
  • Start Date: June 10, 2020
Rare Obesity Cohorts With Food Behavioral Disorders : Better Diagnosis for Better Treatment