Prospective Study of the Natural History, Immunological and Genetic Characteristics of Preclinical Inflammatory Bowel Disease
The purpose of this study is to evaluate disease progression, in terms of development of symptomatic disease and complications associated with IBD (e.g. fistula, abscess, stricture).
⁃ Patients from cohort A will be included if they fulfill all the following inclusion criteria:
• Male or female ≥18 years of age at baseline.
• New diagnosis of IBD during a CRC screening colonoscopy, based on the criteria from the European Crohn's and Colitis Organization (33, 34).
• Presence of a chronic inflammatory infiltrate and histological diagnosis compatible with IBD.
• The patient must be asymptomatic at diagnosis and without previous symptoms suggestive of IBD.
• Time interval between the index colonoscopy and the baseline visit up to 3 months.
⁃ Patients from cohort B will be included if they fulfill all the following inclusion criteria:
• Male or female ≥18 years of age at baseline.
• Recent diagnosis of IBD, with \<3 months from symptoms onset.
• Time interval between the index colonoscopy and the baseline visit up to 3 months.
⁃ Patients from cohort C will be included if they fulfill all the following inclusion criteria:
• Male or female ≥18 years of age at baseline.
• No endoscopic signs of IBD after a complete ileo-colonoscopy within the CRC screening program.
• Time interval between the index colonoscopy and the baseline visit up to 3 months.