Supplementation of Autologous Fat Grafts with Curcumin Preconditioned Adipose-Derived Stem Cells in the Treatment of Facial Contour Deformities
Status: Recruiting
Location: See location...
Intervention Type: Biological, Other
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
The aim of this study is to evaluate the comparison of therapeutic potential of curcumin preconditioned adipose derived stem cells (ASCs) enrichment fat grafting, naïve ASCs enrichment fat grafting and conventional fat grafting to correct facial contour deformities that cause aesthetic complications in patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 50
Healthy Volunteers: f
View:
• Age 18-50 years (male or female)
• Body-mass index 20-30 kg/m²
• Suitable for liposuction as assessed by the expected cosmetic results
• Provided signed informed consent
Locations
Other Locations
Pakistan
Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC)
RECRUITING
Lahore
Contact Information
Primary
Azra Mehmood, PhD
azra_mehmood@hotmail.com
+92-333-4107008
Backup
Amna Arif, M.Phil.
amnaarif.qureshi@gmail.com
+92-333-4161068
Time Frame
Start Date: 2020-11-20
Estimated Completion Date: 2025-12
Participants
Target number of participants: 24
Treatments
Experimental: Cultured ASCs enrichment fat grafting
Fat graft will be supplemented with naïve ASCs
Experimental: Curcumin-preconditioned ASCs enrichment fat grafting
Fat graft will be augmented with curcumin preconditioned ASCs
Active_comparator: conventional fat grafting
Fat graft will not be supplemented with ex-vivo expanded ASCs
Related Therapeutic Areas
Sponsors
Collaborators: Jinnah Burn and Reconstructive Surgery Centre, Lahore, Higher Education Commission (Pakistan), Centre of Excellence in Molecular Biology, University of the Punjab, Lahore
Leads: University of the Punjab