Learn About Crouzon Syndrome

What is the definition of Crouzon Syndrome?

Crouzon syndrome is a genetic disorder characterized by the premature fusion of certain skull bones (craniosynostosis). This early fusion prevents the skull from growing normally and affects the shape of the head and face.

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What are the causes of Crouzon Syndrome?

Mutations in the FGFR2 gene cause Crouzon syndrome. This gene provides instructions for making a protein called fibroblast growth factor receptor 2. Among its multiple functions, this protein signals immature cells to become bone cells during embryonic development. Mutations in the FGFR2 gene are thought to result in production of an FGFR2 protein with overactive signaling, which causes the bones of the skull to fuse prematurely.

How prevalent is Crouzon Syndrome?

Crouzon syndrome is seen in about 16 per million newborns. It is the most common craniosynostosis syndrome.

Is Crouzon Syndrome an inherited disorder?

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

Who are the top Crouzon Syndrome Local Doctors?
Elite
Highly rated in
21
conditions

University Of Campinas

Campinas, RS, BR 

Cassio Amaral-Raposo is in Campinas, Brazil. Amaral-Raposo is rated as an Elite expert by MediFind in the treatment of Crouzon Syndrome. They are also highly rated in 21 other conditions, according to our data. Their top areas of expertise are Craniofrontonasal Dysplasia, Syndactyly, Acromicric Dysplasia, and Pfeiffer Syndrome.

Elite
Highly rated in
5
conditions

Sophia's Children's Hospital Rotterdam

Department Of Oral And Maxillofacial Surgery, The Dutch Craniofacial Centre, Erasmus University Medical Centre 
Rotterdam, ZH, NL 

Cornelia Caron is in Rotterdam, Netherlands. Caron is rated as an Elite expert by MediFind in the treatment of Crouzon Syndrome. She is also highly rated in 5 other conditions, according to our data. Her top areas of expertise are Treacher Collins Syndrome, Acrofacial Dysostosis Rodriguez Type, Acrofrontofacionasal Dysostosis Syndrome, and Goldenhar Disease.

 
 
 
 
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Distinguished
Highly rated in
21
conditions

Great Ormond Street Hospital For Children

Craniofacial Unit 
London, ENG, GB 

David Dunaway is in London, United Kingdom. Dunaway is rated as a Distinguished expert by MediFind in the treatment of Crouzon Syndrome. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are Crouzon Syndrome, Treacher Collins Syndrome, Acrofacial Dysostosis Rodriguez Type, and Acrofrontofacionasal Dysostosis Syndrome.

What are the latest Crouzon Syndrome Clinical Trials?
Study of Therapeutic Outcomes and Practices in Freeman-Sheldon Syndrome
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Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Who are the sources who wrote this article ?

Published Date:updated Last, January

Published By: National Institutes of Health

What are the Latest Advances for Crouzon Syndrome?
Mandibular Distraction Osteogenesis First for Children With Severe Unilateral Hemifacial Microsomia: Treatment Strategy and Outcomes.
Three-dimensional surgical management of a patient with Pruzansky I hemifacial microsomia and severe facial asymmetry: A 4-year follow-up.
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Phenotype and Genotype Study in a Case of Frontometaphyseal Dysplasia 1.