Learn About Cryoglobulinemia

What is the definition of Cryoglobulinemia?

Cryoglobulinemia is the presence of abnormal proteins in the blood. These proteins thicken in cold temperatures.

What are the causes of Cryoglobulinemia?

Cryoglobulins are antibodies. It is not yet known why they become solid or gel-like at low temperatures in the laboratory. In the body, these antibodies can form immune complexes that can cause inflammation and block blood vessels. This is called cryoglobulinemic vasculitis. This may lead to problems ranging from skin rashes to kidney failure.

Cryoglobulinemia is part of a group of diseases that cause damage and inflammation of the blood vessels throughout the body (vasculitis). There are three main types of this condition. They are grouped based on the type of antibody that is produced:

  • Type I
  • Type II
  • Type III

Type I cryoglobulinemia is most often related to cancer of the blood or immune systems.

Types II and III are also referred to as mixed cryoglobulinemia.

Types II and III are most often found in people who have a long-lasting (chronic) inflammatory condition, such as an autoimmune disease or hepatitis C. Most people with the type II form of cryoglobulinemia have a chronic hepatitis C infection.

Other conditions that may be related to cryoglobulinemia include:

  • Leukemia
  • Multiple myeloma
  • Primary macroglobulinemia
  • Rheumatoid arthritis
  • Systemic lupus erythematosus
What are the symptoms of Cryoglobulinemia?

Symptoms will vary, depending on the type of disorder you have and the organs that are involved. Symptoms may include:

  • Breathing problems
  • Fatigue
  • Glomerulonephritis (kidney inflammation)
  • Joint pain
  • Muscle pain
  • Purpura
  • Raynaud phenomenon
  • Skin death
  • Skin ulcers
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What are the current treatments for Cryoglobulinemia?

MIXED CRYOGLOBULINEMIA (TYPES II AND III)

Mild or moderate forms of cryoglobulinemia can often be treated by taking steps to deal with the underlying cause.

Current direct-acting medicines for hepatitis C eliminate the virus in nearly all people. As hepatitis C goes away, the cryoglobulins will disappear in about one half of all people over the next 12 months. Your provider will continue to monitor the cryoglobulins after treatment.

Severe cryoglobulinemia vasculitis involves vital organs or large areas of skin. It is treated with corticosteroids and other medicines that suppress the immune system.

  • Rituximab is an effective drug and has fewer risks than other medicines.
  • Cyclophosphamide is used in life-threatening conditions where rituximab is not working or available. This medicine was used more often in the past.
  • A treatment called plasmapheresis is also used. In this procedure, blood plasma is taken out of blood circulation and abnormal cryoglobulin antibody proteins are removed. The plasma is replaced by fluid, protein, or donated plasma.

TYPE I CRYOGLOBULINEMIA

This disorder is due to a cancer of the blood or immune system such as multiple myeloma. Treatment is directed against the abnormal cancer cells that produce the cryoglobulin.

Who are the top Cryoglobulinemia Local Doctors?
Distinguished in Cryoglobulinemia
Hematology Oncology | Hematology | Oncology
Distinguished in Cryoglobulinemia
Hematology Oncology | Hematology | Oncology
3319 Kings Hwy 1j, 
Brooklyn, NY 
 (22.7 mi)
Languages Spoken:
English
Offers Telehealth

Ilya Blokh is a Hematologist Oncology specialist and a Hematologist in Brooklyn, New York. Dr. Blokh and is rated as a Distinguished provider by MediFind in the treatment of Cryoglobulinemia. His top areas of expertise are Platelet Storage Pool Deficiency, Glanzmann Thrombasthenia, Bernard-Soulier Syndrome, and Gray Platelet Syndrome.

Experienced in Cryoglobulinemia
Hematology | Oncology
Experienced in Cryoglobulinemia
Hematology | Oncology

Msk Monmouth

480 Red Hill Rd, 
Middletown, NJ 
 (5.0 mi)
Experience:
15+ years
Languages Spoken:
English
Accepting New Patients
Offers Telehealth

Colette Owens is a Hematologist and an Oncologist in Middletown, New Jersey. Dr. Owens has been practicing medicine for over 15 years and is rated as an Experienced provider by MediFind in the treatment of Cryoglobulinemia. Her top areas of expertise are Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma (DLBCL), B-Cell Lymphoma, and Follicular Lymphoma. Dr. Owens is currently accepting new patients.

 
 
 
 
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Advanced in Cryoglobulinemia
Hematology Oncology | Oncology | Hematology
Advanced in Cryoglobulinemia
Hematology Oncology | Oncology | Hematology

Barnabas Health Medical Group PC

225 Williamson St, Fl 1, 
Elizabeth, NJ 
 (19.2 mi)
Languages Spoken:
English

Miguel Conde is a Hematologist Oncology specialist and an Oncologist in Elizabeth, New Jersey. Dr. Conde and is rated as an Advanced provider by MediFind in the treatment of Cryoglobulinemia. His top areas of expertise are Non-Hodgkin Lymphoma, Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma, and Anemia.

What is the outlook (prognosis) for Cryoglobulinemia?

Most of the time, mixed cryoglobulinemia does not lead to death. Outlook can be poor if the kidneys are affected.

What are the possible complications of Cryoglobulinemia?

Complications include:

  • Bleeding in the digestive tract (rare)
  • Heart disease (rare)
  • Skin infections or ulcers
  • Kidney failure
  • Liver failure
  • Skin death
  • Death
When should I contact a medical professional for Cryoglobulinemia?

Contact your provider if:

  • You develop symptoms of cryoglobulinemia.
  • You have hepatitis C and develop symptoms of cryoglobulinemia.
  • You have cryoglobulinemia and develop new or worsening symptoms.
How do I prevent Cryoglobulinemia?

There is no known prevention for the condition.

  • Staying away from cold temperatures may prevent some symptoms.
  • Testing and treatment for hepatitis C infection will reduce your risk.
What are the latest Cryoglobulinemia Clinical Trials?
Registry for Adults With Plasma Cell Disorders (PCD's)

Summary: The primary purpose of this protocol is to create a registry of patients with plasma cell disorders (PCDs), including for example the cancer multiple myeloma (MM), who complete the assessment, previously known as a geriatric assessment, as is outlined in this protocol. Secondary objectives include measuring the response rate to participation of patients in this study, assessing patient satisfactio...

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Multicenter Randomized Double-blind Study Comparing the Efficacy and Safety of Belimumab in the Treatment of Non-infectious Active Cryoglobulinemia Vasculitis Compared to Placebo. TRIBECA STUDY (Treatment nd BElimumab in Cryoglobulinemia Associated Vasculitis)

Summary: Cryoglobulinemia vasculitis (CV) is a systemic immune-mediated small vessel vasculitis. Rituximab proved effective on main vasculitis signs, with a complete clinical response of 65%. However, CV relapse is noted in up to 40% of patients. Following rituximab, serum Blys concentration significantly increased and may favor relapses. Tribeca is a multicentre randomized controled study comparing safety...

Who are the sources who wrote this article ?

Published Date: January 25, 2023
Published By: Neil J. Gonter, MD, Assistant Professor of Medicine, Columbia University, NY and private practice specializing in Rheumatology at Rheumatology Associates of North Jersey, Teaneck, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

DiGuardo MA, Bobr A, Winters JL. Hemapheresis. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 38.

Roccatello D, Saadoun D, Ramos-Casals M, et al. Cryoglobulinaemia. Nat Rev Dis Primers. 2018;4(1):11. PMID: 30072738 pubmed.ncbi.nlm.nih.gov/30072738/.

Stone JH. Immune complex-mediated small-vessel vasculitis. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 96.