A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Participants are seeking to unleash the full therapeutic potential of a newly developed, customizable and potentially commericializable 10-channel Functional Electrical Stimulation (FES) to rehabilitate the gait of chronic stroke survivors. Patricipants will utilize the theory of muscle synergies from motor neurosciences, which are defined as neural modules of motor control that coordinate the spatiotemporal activation patterns of multiple muscles, to guide our personal selections of muscles for FES. Before applying FES stimulations to chronic stroke survivors, participants will have to define normal muscle synergies from age-matched healthy control participants (1 session for each participant). After comparing the difference in muscle synergies in both healthy subjects and chronic stroke survivors, participants are attempting to rehabilitate the gait of chronic stroke survivors by using the wearable. Each chronic stroke survivor will undergo 18-session FES training (\ 1 month). It is hypothesized that FES will promote motor recovery by supplying the missing normal muscle synergies to chronic stroke survivors at their supposed times of activations in each step cycle during interventional training. It is also expected that the walk synergies of the paretic side of chronic stroke survivors should be more similar to healthy muscle synergies at the two post-training time points than before training. The healthy normal muscle synergies will be defined by EMG recordings from the recruited healthy participants.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 85
Healthy Volunteers: t
View:

⁃ For chronic stroke survivors:

• Right-handed elderly chronic stroke survivors; age ≥40; ≥6 months post-stroke

• Unilateral ischemic brain lesions

• Participants should be able to walk continuously for ≥15 min. with or without assistive aid

⁃ For healthy participants:

• Healthy, right-handed subjects, age ≥40, free from any history of major neurological, musculoskeletal, and psychiatric disorders

• Able to walk continuously for ≥20 min. without fatigue.

Locations
Other Locations
Hong Kong Special Administrative Region
The Hong Kong Polytechnic University
RECRUITING
Hong Kong
Contact Information
Primary
Vincent Chi Kwan Cheung, PhD
vckc@cuhk.edu.hk
+852 3943 9389
Backup
Roy Tsz Hei Cheung, PhD
roy.cheung@polyu.edu.hk
+852 2766 6739
Time Frame
Start Date: 2021-07-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 90
Treatments
Healthy participants
Measurement of lower-limb muscle activation from healthy participants.
Chronic Stroke Survivors
Measurement of lower-limb muscle activation from chronic stroke survivors
Related Therapeutic Areas
Sponsors
Collaborators: City University of Hong Kong, Shanghai Jiao Tong University School of Medicine, The Hong Kong Polytechnic University
Leads: Chinese University of Hong Kong

This content was sourced from clinicaltrials.gov