Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 85
Healthy Volunteers: f
View:

• aged 25-85

• must be greater than 6 months post-stroke

• must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production

• must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage

• must be stimulable for naming

Locations
United States
New Mexico
University of New Mexico Center for Brain Recovery and Repair
RECRUITING
Albuquerque
Contact Information
Primary
Jessica Richardson, Ph.D.
jdrichardson@unm.edu
505 277-1765
Backup
Honey Hubbard
hhubbard@unm.edu
505-433-7766
Time Frame
Start Date: 2022-10-18
Estimated Completion Date: 2027-04-30
Participants
Target number of participants: 50
Treatments
Active_comparator: Experimental: Active cathodal tDCS + Speech-language training
In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of active tDCS (x 30 minutes of stimulation) combined with 1 hour simultaneous speech-language training on consecutive weekdays.
Sham_comparator: Comparator: Placebo cathodal tDCS + Speech-language training
In this arm, 31 patients with stroke induced Aphasia will undergo 15 sessions of sham tDCS (x 30 minutes sham) combined with 1 hour simultaneous speech-language training on consecutive weekdays..
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH)
Leads: University of New Mexico

This content was sourced from clinicaltrials.gov