Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 120
Healthy Volunteers: f
View:

• Male or female patients

• 18 Years and older

• No history of atrial fibrillation

• CHA2DS2VASC score ≥3

• History pf type II diabetes

• History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease

Locations
United States
Louisiana
Tulane University Medical Center
RECRUITING
New Orleans
Contact Information
Primary
Quintrele Jones, MPH
qjones1@tulane.edu
504-988-3063
Time Frame
Start Date: 2021-04-26
Estimated Completion Date: 2026-01
Participants
Target number of participants: 120
Treatments
Other: Patient arm
All patients will undergo a CMR to evaluate for LA and LAA high-risk features on either a 1.5 or 3 Tesla clinical MR scanner. Gadolinium injection will be administered. Gadolinium is a contrast product that helps define areas of fibrosis in the LA.~High-resolution brain MRI with no contrast will include the following sequences for most accurate assessment of embolic lesions: 3D T1 MPRAGE, 3D FLAIR, DWI, ADC, and SWI
Related Therapeutic Areas
Sponsors
Leads: Tulane University

This content was sourced from clinicaltrials.gov