Cognition as a Moderator of Motor Learning Post-stroke

Who is this study for? Patients with Stroke
What treatments are being studied? Explicit Motor Learning+Implicit Motor Learning
Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 85
Healthy Volunteers: f
View:

• Unilateral stroke

• Stroke occurred more than 6 months prior

• Paresis confined to one side

• Independently ambulatory (including the use of assistive devices)

• Able to walk for 5 minutes without stopping

• Answers no to all general health questions on the PAR-Q+

• Willingness to complete study procedures

Locations
United States
California
Center for Health Professions
RECRUITING
Los Angeles
Contact Information
Primary
Kristan Leech, PT, DPT, PhD
kleech@pt.usc.edu
(323) 442-1583
Backup
Sarah Kettlety, MS
kettlety@usc.edu
(323) 442-1196
Time Frame
Start Date: 2023-01-16
Estimated Completion Date: 2026-12-14
Participants
Target number of participants: 65
Treatments
Experimental: Evaluating motor learning and brain structures post-stroke
We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke
Related Therapeutic Areas
Sponsors
Leads: University of Southern California

This content was sourced from clinicaltrials.gov