Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke (TRAINS): Neuromodulatory Intervention to Ameliorate Cognition After Stroke for Individuals At Risk for VCID.
Status: Recruiting
Location: See location...
Intervention Type: Device, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients with subacute stroke.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:
• Stroke that occurred within 4 weeks of the study
• Presence of cognitive impairment attributable to stroke
• Between the ages of 18 and 90
• Able to understand the nature of the study and give informed consent
• Able to follow simple commands as evidenced by NIHSS subtest 1C =0
Locations
United States
Pennsylvania
Penn Medicine Rehabilitation
RECRUITING
Philadelphia
Contact Information
Primary
Daniela Sacchetti, MS
danielas@pennmedicine.upenn.edu
215-572-8485
Backup
Kelly Sloane, MD
kelly.sloane@pennmedicine.upenn.edu
Time Frame
Start Date: 2021-09-21
Estimated Completion Date: 2027-01
Participants
Target number of participants: 70
Treatments
Active_comparator: Transcranial Direct Current Stimulation (tDCS) + cognitive therapy
Participants will undergo 5 daily sessions of tDCS for 20 minutes using a montage in which an anode (2 mA) is placed over left dorsolateral prefrontal cortex and the cathode will be place on the right supraorbital area. Subjects will participate in cognitive therapy during stimulation.
Sham_comparator: Sham Transcranial Direct Current Stimulation (tDCS) + cognitive therapy
Participants will undergo 5 daily sessions of sham tDCS for 20 minutes using a montage in which an anode (2 mA) is placed over left dorsolateral prefrontal cortex and the cathode will be place on the right supraorbital area. Subjects will participate in cognitive therapy during stimulation.
Related Therapeutic Areas
Sponsors
Leads: University of Pennsylvania