Cerebral Autoregulation in Patients With Symptomatic Cerebral Atherosclerotic Stenosis
In this multi-center prospective observational study within a cohort of symptomatic cerebral atherosclerotic stenosis (sCAS) patients, 850 subjects were planed to be enrolled to explore the relationship between cerebral autoregulation (CA) and stroke recurrence, determine the threshold values of CA parameter for predicting stroke recurrence associated with particular stenosis.
• Age ranging from 18 to 80, both genders
• Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%)
• Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area
• Onset of disease \<30 d before enrollment
• Modified Ranking Scale (mRS) ≤1 before stroke onset
• National Institutes of Health Stroke Scale (NIHSS) ≤20
• Sufficient bilateral temporal bone windows for insonation of the middle cerebral artery
• Be conscious, and able to cooperate with CA assessment
• Willing to participate and sign the informed consent