Recovery and Outcomes From Stroke-Longitudinal Assessment With Neuroimaging

Status: Recruiting
Location: See all (7) locations...
Study Type: Observational
SUMMARY

The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive decline of patients 12 to 24 months post intracerebral hemorrhage (ICH) with long term cognitive follow-up to 36 months on average. This proposal would represent the largest, and longest advanced neuroimaging and RNA-sequencing evaluation after ICH to date.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age 18 years or greater, fulfillment of the criteria for Deep, Subcortical or Lobar Intracerebral Hemorrhage

• No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of ICH.

• Ability of the patient or legal representative to provide informed consent

Locations
United States
Illinois
University of Illinois Chicago
RECRUITING
Chicago
Kentucky
Baptist Health Louisville
RECRUITING
Louisville
Maryland
University of Maryland
RECRUITING
Baltimore
North Carolina
Duke University
RECRUITING
Durham
New York
Columbia University
RECRUITING
New York
Ohio
University of Cincinnati
RECRUITING
Cincinnati
Texas
Houston Methodist
RECRUITING
Houston
Contact Information
Primary
Lee A Gilkerson, RN, BSN
Lee.gillkerson@uc.edu
5139191822
Time Frame
Start Date: 2020-09-30
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 250
Treatments
Participants will be recruited from the GERFHS/ROSE Study
Participants will be recruited who have had a hemorrhagic stroke and have been enrolled into the Genetic and Environmental Risk Factors for Hemorrhagic Stroke Study/Recovery and Outcomes from Stroke study, who live in the area of University of Cincinnati, University of Maryland, Duke University, Columbia University and University of Chicago Illinois, Baptist Health Louisville and Houston Methodist. The participant's age must be18 years or greater. The participant or legal representative must be able to provide informed consent, and the racial/ethnic category of participants should be Caucasian, African American or Hispanic.
Related Therapeutic Areas
Sponsors
Collaborators: University of Maryland, Baltimore, Baptist Health, Louisville, Columbia University, Duke University, The Methodist Hospital Research Institute, University of Illinois at Chicago, National Institute of Neurological Disorders and Stroke (NINDS)
Leads: State University of New York at Buffalo

This content was sourced from clinicaltrials.gov