AtheroGEnic LipoprotEinS in Ischemic Stroke: The AGELESS Study

Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY

Apolipoprotein B (apoB) levels (which encompass all atherogenic lipoproteins, including LDL), Lp(a) levels, and carotid IPH are associated with both first-ever and recurrent ischemic stroke. This cohort research project is to analyze: 1. Among patients with carotid artery atherosclerosis (stenosis 30-99%), to compare patients with and without IPH, as assessed by magnetic resonance (MR)-Plaque Imaging, in terms of apoB, Lp(a) levels and other cardiovascular risk factors. (IPH is a strong morphological sign of plaque vulnerability / instability and a strong marker of consecutive atheroembolic events). 2. Among patients with carotid artery atherosclerosis (stenosis 30-99%), to assess the risk of first-ever ischemic stroke in relation to apoB, Lp(a) levels, and presence of IPH, after adjusting for the cardiovascular factors (understanding this association can inform primary prevention). 3. Among patients with carotid artery atherosclerosis (stenosis 30-99%) with an ipsilateral ischemic stroke at baseline, to assess the risk of recurrent ipsilateral ischemic stroke in relation to apoB, Lp(a) levels, and presence of IPH, after adjusting for the cardiovascular factors. There will be a sensitivity analysis to assess if the association between Lp(a) and recurrent stroke is stronger in patients \<60 years of age. (understanding this association can inform secondary prevention). For the first and second aim, there will be a cross-sectional, case-control analysis. For the third aim, i.e. assessing recurrent ischemic stroke, there is prospective follow-up of at least 3 months up to 45 months.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:

• Atherosclerotic carotid stenosis, North American Symptomatic Trial Collaborators (NASCET) method 30-99%

• Ability to undergo a neck MR for carotid plaque imaging

• Ability to undergo a follow-up of at least 1-year

• For the prospective, longitudinal part: Hemispheric ischemic stroke or retinal ischemia ipsilateral to the carotid stenosis, with symptom onset within 24 hours (these patients will be followed-up for recurrent ischemic stroke)

Locations
Other Locations
Switzerland
University Hospital Basel, Department of Neurology/Stroke Center
RECRUITING
Basel
University Hospital Zürich
NOT_YET_RECRUITING
Zurich
Contact Information
Primary
Gian Marco De Marchis, PD Dr. med.
gian.demarchis@usb.ch
+41 61 265 25 25
Backup
Salome Rudin
salome.rudin@usb.ch
+41 61 265 25 25
Time Frame
Start Date: 2021-09-20
Estimated Completion Date: 2025-12
Participants
Target number of participants: 500
Treatments
1. Patients with and without carotid IPH
Among patients with carotid artery atherosclerosis (stenosis 30-99%), patients with and without IPH, as assessed by MR-Plaque Imaging, are compared in terms of apoB, Lp(a) levels and other cardiovascular risk factors.
2. Patients with and without first-ever ischemic stroke at baseline
Among patients with carotid artery atherosclerosis (stenosis 30-99%), the risk of first-ever ischemic stroke in relation to apoB, Lp(a) levels, and presence of IPH is assessed, after adjusting for the cardiovascular factors.
3. Patients with and without recurrent ischemic stroke
Among patients with carotid artery atherosclerosis (stenosis 30-99%) with an ipsilateral ischemic stroke at baseline, the risk of recurrent ipsilateral ischemic stroke in relation to apoB, Lp(a) levels, and presence of IPH is assessed, after adjusting for the cardiovascular factors.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Basel, Switzerland
Collaborators: Swiss National Science Foundation

This content was sourced from clinicaltrials.gov