Evaluation of the Efficacy and Safety of Mepivacaine on the Neurological Sequelae of Cerebral Infarction
A patient, suffering from cortical blindness after a bi-occipital infarction 1 year earlier, regained near-normal vision in the right visual hemifield a few minutes after subcutaneous administration of mepivacaine. The effect was maintained for several days, and was repeated with each injection of mepivacaine. This clinical improvement is associated with functional changes in the peri-lesional areas on resting-state functional MRI. The investigator team hypothesizes that in some patients with chronic neurological symptoms of stroke, the investigator team will observe a favorable response to subcutaneous mepivacaine injection.
• Ischemic stroke more than 30 days old
• Age between 18 and 85 years old
• At least one deficit among:
• motor deficit: score \< 56 on the Fugl-Meyer scale
• aphasia: score ≥4 on the Aphasia Rapid Test,
• presence of a clinically observable visual scotoma
• Having given their written consent
• Be affiliated with a social security scheme, Universal Medical Coverage (CMU) or any equivalent scheme