Changing Practice: Prognosis and Diagnosis of Spasticity in Acute-post Stroke Patients: a Pilot Study

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Spasticity, or greater muscle resistance, is a major disabling condition following stroke. Recovery of lost motor function in patients with stroke may be affected by spasticity, which most commonly develops in elbow and ankle muscles. However, despite its clinical relevance, the natural development of spasticity over the first 3 months after stroke is not clearly understood. Indeed, common clinical measures of spasticity such as the Modified Ashworth Scale (MAS) do not take into account the neurophysiological origin of spasticity and lack reliability and objectivity. The objective of this study is to examine the natural history of the development of spasticity among patients with stroke over the first 3 months using a new neurophysiological measure (TSRT, the tonic stretch reflex threshold angle) and its velocity sensitivity (mu) in comparison to MAS and other common clinical tests. In addition, detailed brain imaging will be used to understand the relationship between damage to brain regions relevant to the development of spasticity and TSRT/mu values. It is hypothesized that 1) TSRT/mu will indicate the presence of spasticity earlier than MAS/clinical tests; 2) TSRT/mu measures will be more closely related to motor impairments and activity limitations than MAS; 3) the lesion severity (identified by imaging) will be related to the change in TSRT/mu values. Outcomes will be measured in a pilot cohort of 12 patients hospitalized for first-ever stroke. Measurements will be taken at the bedside within the 1st week of the patient's admission and will be done once per week for 12 weeks with a follow-up at week 16. Brain Imaging will be done around the 6th week post-stroke.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• Acute stroke in Middle Cerebral Artery area resulting in hemiparesis.

• Hemorrhagic or ischemic

• Medically stable

• Able to provide informed consent

Locations
Other Locations
Canada
Jewish General Hospital
RECRUITING
Montreal
Contact Information
Primary
Mindy F. Levin, PT, PhD
mindy.levin@mcgill.ca
450-688-9550
Backup
Alice Misana, PT
alice.misana@mail.mcgill.ca
450-688-9550
Time Frame
Start Date: 2021-06-17
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 12
Treatments
Acute stroke patients
12 weekly evaluations starting within the first week post-stroke. Follow-up assessment at week 16. MRI at week 6.
Related Therapeutic Areas
Sponsors
Leads: McGill University

This content was sourced from clinicaltrials.gov