Laying the Groundwork for Personalized Medicine in Aphasia Therapy: Genetic and Cognitive Predictors of Restorative Treatment Response

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:

• At least six months post-onset of a single left-hemisphere stroke

• Chronic aphasia

• Anomia (word-retrieval deficits)

• Native English Speaker.

Locations
United States
Ohio
The Ohio State University
RECRUITING
Columbus
Contact Information
Primary
Stacy Harnish, PhD, CCC-SLP
aphasialab@osu.edu
6146881471
Backup
Grace Terry, MA, CFY-SLP
terry.310@buckeyemail.osu.edu
Time Frame
Start Date: 2020-10-23
Estimated Completion Date: 2025-08
Participants
Target number of participants: 120
Treatments
Experimental: Single Arm Treatment
Cued picture naming therapy will be delivered to all participants. There will be four cohorts of participants based on BDNF and ApoE genotypes.
Related Therapeutic Areas
Sponsors
Collaborators: Nationwide Children's Hospital
Leads: Ohio State University

This content was sourced from clinicaltrials.gov

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